| Objective To investigate the diagnostic value of peripheral blood neutrophil to lymphocyte ratio (NLR), neutrophil CD64 index and procalcitonin (PCT) in ventilator-associated pneumonia (VAP). Methods From January 2018 to June 2019, 124 patients who received mechanical ventilation for 48 hours in the Department of Critical Medicine, the First People's Hospital of Bengbu City, Anhui Province were selectedand divided into VAP group (76 cases) and non VAP group (48 cases), and another 60 healthy people were selected as healthy control group. The levels of NLR, CD64 index and PCT in peripheral blood were detected and compared among the three groups at the time of admission and on the 3 d and 7 d of treatment in VAP group. The value of NLR, CD64 index and PCT in the diagnosis of VAP was analyzed by ROC curve. Results NLR, CD64 index and PCT in VAP group were significantly higher than those in non VAP group and healthy control group, and those in non VAP group were significantly higher than those in healthy control group (P<0.05); NLR, CD64 index and PCT of VAP group were significantly lower than those at 3 d and 7 d after treatment, and those of 7 d after treatment were significantly lower than those of 3 d after treatment (P<0.05). ROC results showed that the area under the curve (AUC) of NLR, CD64 index and PCT diagnosis of VAP was 0.709, 0.888 and 0.864 respectively, and the best cut-off values were 7.33, 4.69 and 0.72 ng/mL. Conclusions Peripheral blood NLR, CD64 index and PCT significantly increased in VAP patients, which have positive significance for the early diagnosis of VAP, and CD64 index has the highest diagnostic value. |
