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| 血清基质细胞衍生因子-1水平与糖尿病周围神经病变的相关性 |
| Association of stromal cell-derived factor 1 with diabeticperipheral neuropathy |
| 投稿时间：2020-11-16 |
| DOI：10.3969/j.issn.1000-0399.2021.04.004 |
| 中文关键词: 糖尿病 糖尿病周围神经病变 基质细胞衍生因子-1 |
| 英文关键词: Diabetes Diabetic peripheral neuropathy Stromal cell-derived factor-1 |
| 基金项目:国家自然科学基金项目（项目编号：81971264，81800713），中国科学院脑功能与脑疾病重点实验室开放课题（项目编号：2019-5），安徽省中央引导地方科技发展专项资金（项目编号：2017070802D147） |
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| 中文摘要: |
| 目的 探索基质细胞衍生因子-1（SDF-1）与糖尿病周围神经病变（DPN）的相关性。方法 回顾性分析2018年9月至2019年10月中国科学技术大学附属第一医院（安徽省立医院）内分泌科138例2型糖尿病患者的临床资料，根据有无神经病变，分为无DPN组与DPN组，每组69例。探讨SDF-1与DPN发病的关系。结果 DPN组患者SDF-1水平为（0.33±0.17）μg/mL，低于无DPN组，差异有统计学意义（P<0.05）；Spearman分析结果显示，SDF-1水平与病程呈负相关（r=-0.178，P<0.05）；logistic回归分析显示，血清SDF-1水平降低、病程可能是影响DPN发病的因素（P<0.05）。结论 SDF-1水平降低可能与DPN的发病有关。 |
| 英文摘要: |
| Objective To explore the association of stromal cell-derived factor-1 (SDF-1) with diabetic peripheral neuropathy (DPN) in diabetes. Methods A retrospective analysis was performed on the clinical data of 138 patients with type 2 diabetes (T2DM) in the First Affiliated Hospital of USTC from September 2018 to October 2019. According to whether they had peripheral neuropathy, patients were divided into non-DPN group(69 cases) and DNP group(69 cases).The relationship between SDF-1 and the occurrence of DPN was analyzed. Results The level of serum SDF-1 in DPN group was(0.33±0.17) μg/mL, lower than that in non-DNP group. The difference between the two groups was statistically significant (P<0.05). Spearman analysis showed that SDF-1 was negatively associated with the course of disease (r=-0.178,P<0.05). Logistic regression analysis showed that the decreased serum SDF-1 level and the disease term were the factors for the occurrence of DPN (P<0.05).Conclusion Decreased serum SDF-1 level may be associated with DPN in diabetes. |
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