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| 老年非小细胞肺癌患者125I放射性粒子植入术后疗效及对患者衰弱状态和癌性疼痛的影响 |
| Evaluation of curative effect, weakness and cancer pain after 125I radioactive seed implantation in elderly patients with non-small cell lung cancer |
| 投稿时间：2021-01-07 |
| DOI：10.3969/j.issn.1000-0399.2021.07.005 |
| 中文关键词: 放射性粒子 非小细胞肺癌 衰弱状态 癌性疼痛 生存曲线 |
| 英文关键词: Radioactive particles Non-small cell lung cancer Weakness Cancer pain Survival curve |
| 基金项目:安徽医科大学校基金资助项目（项目编号：2020xkj016） |
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| 中文摘要: |
| 目的 评价125I放射性粒子植入术联合静脉化疗治疗老年非小细胞肺癌（NSCLC）患者的临床疗效及其对患者整体衰弱状态和癌性疼痛的干预效果。方法 对2016年1月至2019年12月收住安徽医科大学第一附属医院老年呼吸与危重症学科的80例老年NSCLC患者进行回顾性分析，根据治疗方式不同分为试验组和对照组，各40例。试验组为经计算机断层扫描（CT）引导下徒手植入125I放射性粒子的局部介入治疗后继续联合静脉化疗的患者，对照组为单一接受静脉化疗的患者。比较两组接受治疗后6个月的总有效率，治疗前、治疗后1个月及6个月分别采用Fried衰弱表型量表（FP）评估两组患者衰弱状态和采用视觉模拟评分法（VAS）评估两组癌痛评分；绘制生存曲线比较两组生存情况。结果 在治疗后6月，试验组临床治疗有效率高于对照组，差异有统计学意义（χ2=10.470，P=0.001）。两组不同时间点FP、VAS评分进行重复测量资料方差分析，组间FP、VAS评分水平存在差异（P<0.05），同时存在时间效应（P<0.05）。试验组生存时间大于对照组，差异有统计学意义（χ2=4.239，P=0.039）。结论 125I放射性粒子局部介入术联合静脉化疗的治疗有效率优于传统静脉化疗的方式，能够有效改善老年NSCLC患者的衰弱状态，缓解癌性疼痛，提高生活质量。 |
| 英文摘要: |
| Objective To assess the clinical efficacy of 125I radioactive seed implantation combined with intravenous chemotherapy in the treatment of elderly patients who had got non-small cell lung cancer(NSCLC), and to analyze its intervention effect on frailty status and cancer pain. Methods A retrospective analysis was performed on 80 elderly patients with advanced non-small cell lung cancer who were hospitalized in the Department of Geriatric Respiratory and Critical Care Medicine at theFirst Affiliated Hospital of Anhui Medical University from January 2016 to December 2019. According to different treatment methods, they were divided into the experimental group and the control group. The experimental group recruited the patients who continued to combine intravenous chemotherapy after the local interventional treatment with 125I radioactive seeds implanted by hand under the guidance of Computed tomography (CT), and the control group were those who received intravenous chemotherapy alone. There was a contrast in the effective rates of the two groups which had received 6 months' treatment.The Fried Frailty Phenotype(FP) scale was applied to judge the frailty status of the two groups, and the visual analogue scale (VAS) was to judge the cancer pain scores of them before treatment, 1 month and 6 months after receiving appropriate treatment.Asurvival curve was drawnto compare the survival between them. Results As for the effective rate of clinical treatment, the experimental group showed higher values 6 months after treatment, and there was a significant difference in statistics(χ2=10.470,P=0.001).Repeated measurement analysis of variance showed that the average level of FP score and VAS score in the experimental group after treatment showed a higher value than that of the other, and there was a significant difference in statistics(P<0.05). The survival time of the experimental group was longer than that of the other, and there was a significant difference in statistics(χ2=4.239,P=0.039). Conclusions 125I radioactive seed local interventional implantation combined with intravenous chemotherapy is more effective than the traditional chemotherapy, which can apparently improve the frailty status of them with NSCLC, reduce the pain caused by cancer, and improve the quality of life of patients. |
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