| Objective To discuss the multivariate logistic regression analysis of the effects of serum VA, VE, oxidative stress injury indexes on the occurrence of preeclampsia in early pregnancy.Methods Retrospective analysis was performed on the clinical data of 5000 pregnant women who underwent regular prenatal examination and delivery in Maternal and Child Health Care Center of Ma'anshan from Jan 2017 to Jan 2019. They were divided into the preeclampsia group (291 cases) and the control group (4709 cases) according to the occurrence of preeclampsia or not during pregnancy. The baseline data, serum VA and VE levels, oxidative stress injury indexes of the pregnant women were recorded and compared; the multivariate logistic regression analysis was used to analyze the risk factors of occurrence of preeclampsia or not during pregnancy. Results The serum VA, VE, MMP-9, PLGF, T-AOC of the preeclampsia group were significantly lower than those of the control group respectively (all P<0.05). The multivariate logistic regression analysis showed that the decrease of VA(OR=1.358, 95%CI:1.141~2.376, VE(OR=1.289, 95%CI:1.043~1.983), MMP-9(OR=1.651, 95%CI:1.238~2.865), PLGF(OR=1.276, 95%CI:1.017~2.144), T-AOC(OR=1.714, 95%CI:1.246~2.491) were independent risk factors of PE during pregnancy (all P<0.05). Conclusions The serum VA and VE levels of pregnant women with PE are significantly lower than those of the normal pregnant women. Lack of VA and VE, decrease of oxidative stress injury index are independent risk factors of PE during pregnancy. |
