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| 高原红细胞增多症患者PDGF TXA2表达与血小板参数及凝血指标的关系 |
| Relationship between PDGF TXA2 expression and platelet parameters and coagulation in patients with high altitude polycythemia |
| 投稿时间：2021-04-10 |
| DOI：10.3969/j.issn.1000-0399.2021.12.005 |
| 中文关键词: 高原红细胞增多症 凝血指标 血小板参数 血小板衍生生长因子 血栓素A2 |
| 英文关键词: High altitude polycythemia Coagulation function Platelet parameter Platelet-derived growth factor Thromboxane A2 |
| 基金项目:青海大学附属医院中青年课题项目（项目编号：ASRF-2019-YB-01），青海省科技计划项目（项目编号：2020-ZJ-956Q），青海省科技厅自然科学基金项目（项目编号：2019-ZJ-902） |
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| 中文摘要: |
| 目的 探讨高原红细胞增多症（HAPC）患者血小板衍生生长因子（PDGF）、血栓素A2（TXA2）的表达与血小板参数和凝血指标关系。方法 选取2018年12月至2019年12月入住青海大学附属医院确诊为HAPC男性患者22例为观察组，同期另选取长期居住于高海拔地区男性25例作为对照组，分别采用酶联免疫吸附法、实时荧光定量多聚核苷酸链式反应法检测两组研究对象PDGF、TXA2的表达，并分析与血小板参数及凝血指标的关系。结果 观察组PDGF、TXA2水平高于对照组，差异有统计学意义（Z=-4.510、-3.027，P<0.05）；观察组血小板指标较对照组偏低，差异有统计学意义（P<0.05）；观察组纤维蛋白原降解产物较对照组延长，差异有统计学意义（P<0.05）；PDGF、TXA2与血小板指标及凝血指标无相关性（P>0.05）。结论 HAPC患者血小板活化，凝血有异常，PDGF、TXA2表达升高，是HAPC患者对高原环境适应机制的组成部分。 |
| 英文摘要: |
| Objective To investigate the relationship between platelet derived growth factor and thromboxane A2 expression and platelet parameters and coagulation indexes in patients with high altitude polycythemia. Methods A total of 622 HAPC patients admitted to the Affiliated Hospital of Qinghai University from December 2018 to December 2019 were selected as the observation group, and 25 male patients living in high altitude area were selected as the control group during the same period. The expressions of PDGF and TXA2 in the two groups were detected by Elisa and real-time fluorescence quantitative method, respectively. The relationship between platelet parameters and coagulation indexes was analyzed. Results The levels of PDGF and TXA2 in HAPC group were higher than those in the control group, and the differences were statistically significant(Z=-4.510,-3.027,P<0.05). The platelet index of the HAPC was lower than that of the control group, and the difference was statistically significant (P<0.05). FDP in the observation group was longer than that in the control group, and the difference was statistically significant (P<0.05). There was no significant correlation between PDGF, TXA2 and platelet index and coagulation index (P>0.05). Conclusions HAPC patients have platelet activation, abnormal coagulation, and increased expression of PDGF and TXA2,which are part of the adaptation mechanism of HAPC patients to the plateau environment. |
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