Objective To investigate the effect of preoperative regional arterial infusion chemotherapy (PRAC) combined with laparoscopic surgery on the expression of serum EGFR, proto oncogene HER-2 and MMP-2 and long-term prognosis of CRC. Methods A total of 164 CRC patients admitted to Shijiazhuang Hospital of Traditional Chinese Medicine from January 2014 to December 2015 were randomly divided into control group (81 cases treated with laparoscopy surgery) and study group (83 cases treated with PRAC combined with laparoscopic surgery). The operation conditions of the two groups were observed, the expression levels of serum EGFR, HER-2, and MMP-2 were measured before and after treatment, the incidence of complications was counted, and the prognosis of 1 and 3 years after treatment, recurrence and metastasis 3 years after treatmentwere compared.Results The intraoperative blood loss of the study group was less than that of the control group (t=8.895, P=0.000). The difference in serum EGFR, HER-2, MMP-2 expression levels before and after treatment between the two groups was statistically significant (t=6.357, 3.509, 6.345,all P<0.05, 0.001, 0.000). There was no significant difference in the total incidence of complications between the two groups (χ2=0.245,P=0.620). The 1-year survival rate of the study group (77/83, 92.77%) was significantly higher than that of the control group (61/81, 75.31%), the 3-year survival rate (52/83, 62.65%) was significantly higher than that of the control group (29/81, 35.80%), and the difference between the two groups was statistically significant (χ2=9.371, 14.039, P=0.002, 0.000). During the follow-up, 19 cases of liver metastasis, lung metastasis, bone metastasis and local recurrence occurred in the study group, and 31 cases in the control group, and the difference between the two groups was statistically significant (χ2=4.576, P=0.032).Conclusions PRAC combined with laparoscopic surgery can reduce the intraoperative blood loss and the expression levels of serum EGFR, HER-2 and MMP-2 in patients with CRC, and it has high long-term survival rate and low recurrence rate. |