文章摘要
乳腺癌患者Lin28A/B水平与乳腺癌转移及血管新生的关系
Relationship between Lin28A/B and metastasis and angiogenesis of breast cancer
投稿时间：2021-08-27  
DOI：10.3969/j.issn.1000-0399.2022.02.004
中文关键词: 乳腺癌  Lin28A  Lin28B  转移  血管新生
英文关键词: Breast cancer  Lin28A  Lin28B  Metastasis  Angiogenesis
基金项目:河北省2021年度医学科学课题研究计划（项目编号：20211657）
作者单位
曹渤海 063000 河北唐山 唐山中心医院病理科 
胡月 063000 河北唐山 唐山中心医院病理科 
明田莉 063000 河北唐山 唐山中心医院病理科 
杨瑞东 063799 河北唐山 滦州市人民医院病理科 
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中文摘要:
      目的 分析RNA结合蛋白（Lin28A/B）在乳腺癌组织中的表达及其与乳腺癌转移及血管新生的关系。方法 将2019年1月至2020年12月唐山中心医院及滦州市人民医院收治的80例乳腺癌患者设为观察组，另纳入唐山中心医院同期门诊健康体检者40例为对照组，比较乳腺癌患者癌组织及癌旁组织中Lin28A/B mRNA的表达量；同时比较观察组及对照组血清癌细胞转移指标基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-9（MMP-9）和血管新生指标血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）和血管内皮抑素（ES）表达水平，采用Pearson相关分析癌组织中Lin28A/B mRNA的表达量与癌细胞转移及血管新生指标的相关性。结果 癌组织中Lin28A/B mRNA的表达量均明显高于癌旁组织，差异有统计学意义（P<0.05）。观察组血清MMP-2及MMP-9，VEGF、bFGF及ES的表达均明显高于对照组，差异有统计学意义（P<0.05）。乳腺癌组织中Lin28AmRNA的表达量与MMP-2、MMP-9、VEGF、bFGF水平明显相关（r=0.523、0.439、0.562、0.461，P<0.05），与ES无相关性（r=0.118，P>0.05）；Lin28B mRNA的表达量与MMP-2、MMP-9、VEGF、bFGF明显相关（r=0.546、0.468、0.527、0.449，P<0.05），与ES无相关性（r=0.106，P>0.05）。结论 Lin28A/B在乳腺癌组织中高表达，其表达量与癌细胞转移指标及血管新生指标呈正相关，可能参与调节乳腺癌的疾病进展。
英文摘要:
      Objective To analyze the expression of RNA binding protein (Lin28A/B) in breast cancer and its relationship with breast cancer metastasis and angiogenesis.Methods A total of 80 breast cancer patients treated in Tangshan Central Hospital and Luanzhou People's Hospital from January 2019 to December 2020 were selected as the observation group, and 40 patients who received physical examination in the outpatient clinic of Tangshan Central Hospital during the same period were recruited as controls to compare with breast cancer patients. The expression of Lin28A/BmRNA in cancer tissues and adjacent tissues of breast cancer patients was compared.At the same time, the expression levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and vascular endostatin (ES) were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between the expression of Lin28A/BmRNA and the indexes of cancer cell metastasis and angiogenesis.Results The expression of Lin28A/BmRNA in cancer tissues was significantly higher than that in paracancerous tissues(P<0.05). The expressions of serum MMP-2, MMP-9,VEGF, bFGF and ES in the observation group were significantly higher than those in the control group(P<0.05).The expression of Lin28A mRNA in breast cancer was significantly correlated with the levels of MMP-2, MMP-9, VEGF and bFGF (r=0.523, 0.439, 0.562, 0.461,P<0.05), but not with ES (r=0.118, P>0.05), while the expression of Lin28B mRNA was significantly correlated with MMP-2, MMP-9, VEGF, bFGF (r=0.546, 0.468, 0.527, 0.449,P<0.05), but not with ES (r=0.106, P>0.05).Conclusions Lin28A/B is highly expressed in breast cancer tissues, and its expression is positively correlated with cancer cell metastasis and angiogenesis, which may be involved in regulating the progression of breast cancer.
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