文章摘要
SF3B1基因在胰腺癌组织中的表达及其与肿瘤分期分化程度的相关性
Expression of SF3B1 gene in pancreatic cancer and its correlation with staging and differentiation
投稿时间：2021-06-04  
DOI：10.3969/j.issn.1000-0399.2022.02.007
中文关键词: SF3B1基因突变  胰腺癌  分化程度  TNM分期
英文关键词: SF3B1 gene mutation  Pancreatic cancer  Degree of differentiation  TNM staging
基金项目:
作者单位E-mail
李靖 710032 陕西西安 空军军医大学第一附属医院消化内镜中心  
王一卓 710032 陕西西安 空军军医大学第一附属医院消化内科 644617128@qq.com 
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中文摘要:
      目的 探讨剪切因子3B亚基1（SF3B1）基因在胰腺癌组织中的表达及其与肿瘤分期、病理程度相关性。方法 回顾性分析2017年9月至2019年8月空军军医大学第一附属医院行根治术治疗的48例胰腺癌患者临床资料，对术中切除的癌组织及癌旁组织行免疫组化染色，比较SF3B1基因在胰腺癌、癌旁组织中的阳性率；根据TNM分期将胰腺癌分为Ⅰ期、Ⅱ期、Ⅲ期及Ⅳ期，根据细胞分化程度分为高分化、中分化、低分化及未分化组，比较胰腺癌不同TNM分期、不同分化程度的SF3B1阳性率；采用Pearson相关分析SF3B1基因阳性率与胰腺癌分化程度、TNM分期的关系。结果 癌旁组织中的SF3B1基因阳性率（77.08%）高于癌灶组织（16.67%），差异有统计学意义（P<0.05）。TNM分期为Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期的患者SF3B1阳性率分别为100.00%、36.36%、6.25%、0.00%，高分化、中分化、低分化、未分化的患者SF3B1阳性率分别为31.25%、13.33%、8.33%、0.00%。Pearson分析显示，SF3B1基因阳性率与胰腺癌分化程度、TNM分期的相关系数分别为0.368、-0.548（P均<0.001）。结论 胰腺癌患者癌旁组织中的SF3B1基因阳性率高于癌灶组织，SF3B1基因阳性率与胰腺癌分化程度呈正相关，SF3B1基因阳性率与胰腺癌TNM分期呈负相关。
英文摘要:
      Objective To investigate the expression of shear factor 3B subunit 1 (SF3B1) gene in pancreatic cancer and its correlation with staging and pathological degree. Methods The clinical data of 48 patients with pancreatic cancer treated by radical operation from the First Affiliated Hospital of Air Force Military Medical University from September 2017 to August 2019 were retrospectively analyzed. Immunohistochemical staining was used to compare the positive rates of SF3B1 gene in pancreatic cancer and paracancerous tissues. According to TNM staging, staging of pancreatic cancer (stage 3, stage II, 11, stage 16, and stage 18) wasdivided into three groups according to the degree of cell differentiation (16 cases of high differentiation, 15 cases of moderate differentiation, 12 cases of poorly differentiated and 5 cases of undifferentiated). The SF3B1 positive rates of different degrees of differentiation and TNM stages of pancreatic cancer were compared. Pearson correlation analysis was used to analyze the relationship between the positive rate of SF3B1 gene and the degree of differentiation and TNM staging of pancreatic cancer. Results The positive rate of sf3b1 gene in adjacent tissues (77.08%) was significantlyhigher than that in cancer tissues (16.67%) (P<0.05). The positive rateof sf3b1 in TNM stages I, II, III and IV was 100.00%, 36.36%, 6.25% and 0.00%, respectively. The positive rate of highly differentiated, moderately differentiated, poorly differentiated and undifferentiated sf3b1 was31.25%, 13.33%, 8.33% and 0.00%, respectively. Pearson analysis showed that the correlation coefficient of SF3B1 gene positive rate with pancreatic cancer differentiation and TNM staging was 0.368 and -0.548 (P<0.001) respectively.Conclusions The positive rate of SF3B1 gene in paracancerous tissues is higher than that in cancer tissues. The positive rate of SF3B1 gene is positively correlated with the degree of differentiation of pancreatic cancer, and the positive rate of SF3B1 gene is negatively correlated with the TNM stage of pancreatic cancer.
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