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| 基于定量磨玻璃样阴影特征的肺癌预后分析研究 |
| The prognostic analysis of lung cancer based on quantitative feature of ground glass opacity |
| 投稿时间：2022-04-20 |
| DOI：10.3969/j.issn.1000-0399.2022.07.008 |
| 中文关键词: 肺腺癌 磨玻璃结节 病理学 计算机断层扫描 |
| 英文关键词: Lung adenocarcinoma Groundglass opacity Pathology Computed tomography |
| 基金项目: |
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| 中文摘要: |
| 目的 基于CT定量分析探讨肺部磨玻璃阴影(GGO)恶性程度及生存预后的意义。方法 回顾性分析2014年12月至2019年10月期间安徽医科大学附属省立医院胸外科收治的112例GGO患者的临床与病理资料,随访时间为3～69个月,平均随访(35.91±1.91)个月。根据实性成分占肿瘤比率(CTR)分为A组19例(CTR≤0.25),B组33例(0.25结果 4组患者病理类型、复发情况及淋巴结转移比较,差异均有统计学意义(P<0.05);Cox回归分析提示CTR是影响GGO生存的独立影响因素;logistics回归分析显示CTR为GGO侵袭性的独立预后因素;A、B组与C、D组的OS与RFS差异具有统计学(P＜0.05),D组淋巴结转移与其他组差异具有统计学意义(P<0.05);绘制CTR、GGO实性最大径及GGO最大径的ROC曲线,提示CTR对GGO的侵袭性与淋巴结转移的有无预测效果最佳,对应的AUC分别为0.807、0.884,最佳截断值分别为0.547、0.800。结论 CTR为GGO预后的独立影响因素,并对GGO的侵袭性及淋巴结转移有着良好的预测效果。 |
| 英文摘要: |
| Objective To explore the prognostic significance of malignant degree and survival of groundglass opacity (GGO) in lungs based on the quantitative analysis of CT.Methods The clinical and pathological data of 112 patients with pulmonary nodules who underwent pneumonectomy in the Department of Thoracic Surgery, Affiliated Provincial Hospital of Anhui Medical University from December 2014 to October 2019 were retrospectively analysed. Based on the consolidation tumor ratio (CTR), the patients were divided into 19 cases in group A (CTR≤0.25), 33 cases in group B (0.25Results The univariate and multivariate logistic analysis of the two groups confirmed that the solid component of GGO accounted for tumor ratio (CTR) was an independent prognostic factor for GGO and an independent risk factor for lymph node metastasis in GGO. Among the four groups subdivided according to the CTR range, the OS and RFS between groups A, B and group C, D were significantly different (P<0.05), and the lymph node metastasis in group D was significantly different from the other three groups (P<0.05). By drawing the ROC curve, the optimal CTR cutoff value of GGO invasiveness was 0.547, AUC=0.807, and the optimal CTR cutoff value of lymph node metastasis was 0.800, AUC=0.884.Conclusion The CTR value can be used to judge the invasion degree of GGO and the presence or absence of lymph node metastasis. |
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