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| CXCL17在慢性乙型肝炎患者中的变化及其与病毒载量和肝纤维化的关系 |
| Changes of CXCL17 in patients with chronic hepatitis B and its relationship with viral load and liver fibrosis |
| 投稿时间：2022-06-13 |
| DOI： |
| 中文关键词: CXC趋化因子家族配基17 慢性乙型肝炎 病毒载量 肝纤维化 |
| 英文关键词: CXC chemokine family ligand 17 Chronic hepatitis B Viral load Liver fibrosis |
| 基金项目:江西省卫生健康委科技计划(项目编号:202219681) |
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| 中文摘要: |
| 目的 探讨CXC趋化因子家族配基17(CXCL17)在慢性乙型肝炎(CHB)患者中的表达及其与病毒载量和肝纤维化的关系。方法 选取2019年6月至2021年6月九江市第一人民医院肝病科收治的50例CHB患者纳入试验组,选取同期50例健康体检者纳入对照组。比较两组血清CXCL17水平,采用Pearson相关性分析CHB患者血清CXCL17水平与谷草转氨酶(AST)、谷丙转氨酶(ALT)、γ-谷氨酰转肽酶(GGT)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、层粘连蛋白(LN)、IV型胶原(CIV)、乙型病毒性肝炎(HBV)DNA的关系。采用直接抽样法随机选取20例CHB患者,经恩替卡韦治疗6个月后,HBV DNA<500拷贝/毫升时,检测血清其CXCL17表达情况。结果 试验组血清CXCL17、AST、ALT、GGT、HA、PCⅢ、LN、CIV水平均高于对照组,CHB患者血小板(PLT)水平低于对照组,差异均有统计学意义(P<0.05);Pearson相关性分析显示,试验组血清CXCL17水平与PLT呈负相关(r=0.501,P<0.05),与AST、ALT、GGT、HA、PCⅢ、LN、CIV、HBV DNA均呈正相关(r=0.653、0.486、0.306、0.610、0.512、0.402、0.412、0.447,P<0.05);治疗后,CHB患者HBV DNA<500拷贝/毫升时,血清CXCL17水平低于治疗前(P<0.05)。结论 CHB患者血清CXCL17水平异常升高,CXCL17水平变化与病毒载量及肝纤维化有关,临床抗病毒治疗可以降低血清CXCL17水平。 |
| 英文摘要: |
| Objective To explore the changes of CXC chemokine family ligand 17 (CXCL17) in patients with chronic hepatitis B (CHB) and its relationship with viral load and liver fibrosis.Methods A total of 50 patients with CHB admitted to the Department of Hepatology, the First People’s Hospital of Jiujiangfrom June 2019 to June 2021 were selected, and 50 healthy subjects were selected during the same period. Serum CXCL17 levels in CHB patients and healthy individuals were compared.Pearson correlation was used to analyze the relationship between serum CXCL17 level and aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), (HA), type Ⅲ procollagen (PCⅢ), laminin (LN), type IV collagen (CIV) , viral hepatitis B (HBV) DNA in CHB patients. Twenty patients with CHB were randomly selected by direct sampling method, and after six months of entecavir treatment, the expression of serum CXCL17 was detectedwhen HBV DNA was less than 500 copies/mL.Results The serum levels of CXCL1, AST, ALT, GGT, HA, PCⅢ, LN, and CIV in CHB patients were higher than those in healthy subjects (P<0.05), and the levels of PLT in CHB patients were lower than those in healthy subjects (P<0.05). Pearson correlation analysis showed that the serum CXCL17 levels were negatively correlated with the level of PLT (r=-0.501) in CHB patients (P<0.05), and CXCL17 levels were positively correlated with the level of AST (r=0.653), ALT (r=0.486), GGT (r=0.306), HA (r=0.610), PCⅢ (r=0.512), LN (r=0.402), CIV (r=0.412), and HBV DNA (r=0.447) (P<0.05). After treatment, when HBV DNA <500 copies/mL in CHB patients, serum CXCL17 level was lower thanthat before treatment (P<0.05).Conclusions The level of serum CXCL17 in CHB patients is abnormally elevated, and the change of CXCL17 level isassociated with viral load and liver fibrosis, and clinical antiviral treatment can reduce the level of serum CXCL17. |
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