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| 血清CTRP4 PAI-1水平对早产儿呼吸窘迫综合征的诊断价值 |
| The diagnostic value of serum CTRP4 and PAI-1 levels for respiratory distress syndrome in premature infants |
| 投稿时间：2022-09-20 |
| DOI：10.3969/j.issn.1000-0399.2023.04.013 |
| 中文关键词: 早产儿呼吸窘迫综合征 C1q/肿瘤坏死因子相关蛋白4 纤溶酶原激活物抑制物 诊断 |
| 英文关键词: Respiratory distress syndrome in premature infants C1q/tumor necrosis factor-related proteins Plasminogenactivatorinhibitor Diagnosis |
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| 中文摘要: |
| 目的 探讨呼吸窘迫综合征（RDS）早产儿血清C1q/肿瘤坏死因子相关蛋白4（CTRP4）、纤溶酶原激活物抑制物（PAI-1）表达情况，分析其临床诊断价值。方法 选取2018年10月至2020年3月在成都市锦江区妇幼保健院出生并确诊的90例RDS早产儿作为RDS组，30例非RDS早产儿作为对照组。采用酶联免疫吸附法检测两组对象血清CTRP4、PAI-1水平；采用Pearson法分析RDS早产儿血清CTRP4、PAI-1表达水平的相关性；采用logistic回归分析早产儿RDS发生的影响因素；采用受试者工作特征（ROC）曲线分析血清CTRP4、PAI-1表达水平对临床诊断的价值。结果 RDS组血清CTRP4、PAI-1水平均高于对照组，且与疾病严重程度呈正比，差异有统计学意义（P< 0.05）。RDS早产儿血清CTRP4水平与PAI-1水平呈正相关（r=0.267，P=0.011）；早产儿窒息、CTRP4水平、PAI-1水平为早产儿RDS发生的影响因素（P< 0.05）。血清CTRP4诊断RDS早产儿的ROC曲线下面积为0.802，灵敏度、特异度分别为80.95%和72.92%；PAI-1的ROC曲线下面积为0.727，灵敏度、特异度分别为71.43%和64.58%；二者联合评估的ROC曲线下面积为0.821，灵敏度、特异度分别为73.81%和81.25%。结论 RDS早产儿血清CTRP4、PAI-1水平明显升高，且随着病情变化而发生改变，CTRP4和PAI-1联合检测对临床诊断RDS早产儿具有重要的意义。 |
| 英文摘要: |
| Objective To investigate the expression of serum C1q/tumor necrosis factor-related proteins (CTRP4) and plasminogenactivatorinhibitor (PAI-1) in premature infants with respiratory distress syndrome (RDS), and to analyze their clinical diagnostic value. Methods A total of 90 premature infants with RDS who were born and diagnosed in Chengdu Jinjiang Maternal and Child Health Hospital from October 2018 to March 2020 were gathered, and 30 non-RDS premature infants born were regarded as the control group. Serum CTRP4 and PAI-1 levels were detected by enzyme-linked immunosorbent assay. Pearson’s method was applied to analyze the correlation of serum CTRP4 and PAI-1 expression levels in premature infants with RDS. Logistic regression was applied to analyze the influencing factors of RDS in preterm infants. Receiver operating characteristic (ROC) curve was applied to analyze the value of serum CTRP4 and PAI-1 expression levels for clinical diagnosis. Results The serum CTRP4 and PAI-1 levels in the RDS group were higher than those in the control group and were positively correlated with disease severity, and the differences were all statistically significant (P< 0.05). CTRP4 level was positively correlated with PAI-1 level (r= 0.267, P=0.011); asphyxia, CTRP4 level and PAI-1 level of premature infants were the influencing factors of RDS in premature infants(P< 0.05). The area under the ROC curve of serum CTRP4 in the diagnosis of RDS premature infants was 0.802, and the sensitivity and specificity was 80.95% and 72.92%, respectively. The area under the ROC curve of PAI-1 was 0.727, and the sensitivity and specificity was 71.43% and 64.58%, respectively. The area under the ROC curve of the combined evaluation was 0.821, and the sensitivity and specificity was 73.81% and 81.25%, respectively. Conclusions The serum levels of CTRP4 and PAI-1 in premature infants with RDS obviously increase, and they change with the condition of the disease. The combined detection of CTRP4 and PAI-1 is of great significance for the clinical diagnosis of premature infants with RDS. |
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