| Objective To observe the clinical efficacy of uterine artery embolization(UAE) combined with curettage in the treatment of cesarean scar pregnancy(CSP). Methods The clinical data of 65 CSP patients treated in Anyang Third People's Hospital from June 2019 to June 2020 were collected and retrospectively analyzed. The control group(n=32) all underwent uterine evacuation, and the study group(n=33) all underwent UAE combined with uterine evacuation. The cure rate, postoperative hospital stay, clinical indicators, short-term/long-term complications, and perinatal pregnancy outcomes of re-pregnancy were compared between the two groups. Results The cure rate of the study group(100%) was higher than that of the control group(81.25%), and the difference was statistically significant(P<0.05); the postoperative hospital stay was shorter than that of the control group, and the difference was statistically significant(P<0.05); the time of menstrual rehydration and the blood beta-human chorionic gonadotropin(β-HCG) normalization time were earlier than those of the control group, and the difference was statistically significant(P<0.05); the number of patients with normal pregnancy in the study group was larger than that in the control group within two years, and the difference was statistically significant(P<0.05). The variance analysis of the repeated measurement of β-HCG at different time points of the two groups showed difference, and there were intergroup differences(P<0.05), concurrent time effect(P<0.05) but no interaction effect(P> 0.05). There was no obvious difference in the incidence of short-term and long-term complications between the two groups(P>0.05). Conclusions UAE combined with uterine evacuation can improve the cure rate of CSP and the rate of normal pregnancy again, promote the return of menstruation and normalization of blood β-HCG, and shorten the postoperative hospital stay of patients without increasing short-term or long-term complications.