文章摘要
糜烂型牙龈口腔扁平苔藓伴牙周炎药物联合牙周基础治疗时机选择
Study on timing selection of erosive gingival oral lichen planus with periodontitis combined with periodontal basic treatment
投稿时间:2023-03-15  
DOI:10.3969/j.issn.1000-0399.2023.11.008
中文关键词: 口腔扁平苔藓  牙周炎  牙周基础治疗  药物治疗
英文关键词: Oral lichen planus  Periodontitis  Periodontal initial therapy  Drug therapy
基金项目:合肥市卫健委应用医学研究项目(编号:Hwk2020yb0018);安徽省重点研究与开发计划项目(编号:2022e070200592);安徽医科大学校科研基金资助(编号:2021xkj250)
作者单位E-mail
陈渊 230032 安徽合肥 合肥市口腔医院(安徽医科大学合肥口腔临床学院)牙周黏膜科  
汪涌 230032 安徽合肥 合肥市口腔医院(安徽医科大学合肥口腔临床学院)牙周黏膜科 yllwywzy@126.com 
韩爽 230032 安徽合肥 合肥市口腔医院(安徽医科大学合肥口腔临床学院)正畸二科  
笪海芹 230032 安徽合肥 合肥市口腔医院(安徽医科大学合肥口腔临床学院)牙周黏膜科  
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中文摘要:
      目的 探索糜烂型牙龈口腔扁平苔藓(OLP)伴牙周炎药物联合牙周基础治疗的时机。方法 选取2020年6月至2022年9月合肥市口腔医院牙周黏膜科就诊的糜烂型牙龈OLP伴牙周炎患者33例,将患者随机分成A组(n=12,药物治疗后1周再行牙周基础治疗)、B组(n=10,牙周基础治疗后1周再给予药物治疗)和C组(n=11,牙周基础治疗与药物治疗同时进行)。观察3组患者治疗前、治疗后1周、治疗后6周牙龈疼痛程度(NRS)变化及治疗前、治疗后6周牙周指标菌斑指数(PLI)、出血指数(BI)、探诊深度(PD)、临床附着丧失(CAL)变化。结果 不同时间点3组患者NRS评分差异无统计学意义(P>0.05),但存在时间效应和交互效应。治疗后1周时,3组NRS评分治疗前后差值差异有统计学意义(P<0.05),A、C组差值均大于B组(P<0.05)。3组治疗前PLI、BI、PD、CAL差异均无统计学意义(P>0.05),治疗后6周均较前改善(P<0.05),但牙周指标(PLI、BI、PD、CAL)治疗前后差值差异均无统计学意义(P>0.05)。结论 药物联合牙周基础治疗不同时机均可改善糜烂型牙龈OLP伴牙周炎患者的临床症状,于牙周基础治疗前1周或同期给予药物治疗能缓解牙周治疗中牙龈疼痛。
英文摘要:
      Objective To explore the timing of erosive gingival oral lichen planus combined with periodontitis drugs and periodontal basic treatment. Methods Thirty-three cases of erosive gingival oral lichen planus with periodontitis patients treated in the Department of Periodontal Mucosa of Hefei Stomatological Hospital from June 2020 to September 2022 were selected, then the patients were randomly divided into group A(n=12, initial periodontal treatment was given one week after drug treatment), Group B(n=10, the drug treatment was given one week after the initial periodontal treatment), and group C(n=11, which received periodontal initial therapy and drug therapy simultaneously) by random sampling method. The changes in the gingival pain(NRS) of patients in three groups were observed respectively before, 1 week and 6weeks after treatment, as well as the plaque index(PLI), bleeding index(BI), probing depth(PD), clinical attachment loss(CAL) were recorded before treatment and 6 weeks after treatment. Results There was no significant difference in NRS scores among the three groups at different time points(P>0.05), but there were time effects and interaction effects. One week after treatment, the difference in NRS scores before and after treatment among thethree groups was statistically significant(P<0.05), and the difference in groups A and C was greater than that of group B(P<0.05). There were no significant differences in PLI, BI, PD and CAL before treatment among the groups(P>0.05), and improvement could beobserved six weeks after treatment(P<0.05), but there was no significant difference in periodontal indexes(PLI, BI, PD, CAL) before and after treatment(P>0.05). Conclusions The clinical symptoms of patients with erosive gingival OLP accompanied by periodontitis can be improved by the combination of drugs and periodontal basic treatment at different time. The drug treatment given 1 week before or at the same time of periodontal basic treatment can relieve the gingival pain during periodontal treatment.
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