文章摘要
TIPE2 Ki67在子宫内膜癌组织中的表达及对预后的评估价值
Expression of TIPE2 and Ki67 in endometrial cancer tissue and their evaluation value for prognosis
投稿时间：2022-11-28  
DOI：10.3969/j.issn.1000-0399.2023.11.012
中文关键词: 子宫内膜癌  肿瘤坏死因子诱导蛋白8样蛋白2  细胞增殖核抗原Ki67  危险因素
英文关键词: Endometrial cancer  Tumor necrosis factor-inducible protein 8-like protein 2  Proliferating nuclear antigen Ki67  Risk factors
基金项目:河北省医学科学研究课题计划（编号：20220667）
作者单位
周丽媛 056002 河北邯郸 河北工程大学附属医院妇科 
施喆 056002 河北邯郸 河北工程大学附属医院普外科 
刘悦君 056002 河北邯郸 河北工程大学附属医院妇科 
李静霞 056002 河北邯郸 河北工程大学附属医院妇科 
崔志利 056002 河北邯郸 河北工程大学附属医院妇科 
安欣 056002 河北邯郸 邯郸市第一医院病理科 
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中文摘要:
      目的 探讨肿瘤坏死因子诱导蛋白8样蛋白2（TIPE2）、细胞增殖核抗原Ki67在子宫内膜癌组织中的表达及对患者预后的评估价值。方法 选取2018年1月至2020年1月河北工程大学附属医院妇科收治的子宫内膜癌患者120例作为观察组，另选取同期收治的非子宫内膜癌患者130例作为对照组，所有入组患者均接受手术治疗。回顾性收集患者的临床及病理资料，比较两组患者子宫内膜组织中TIPE2、Ki67的表达水平。同时定期对观察组患者进行随访，分析患者2年生存情况，通过Cox比例风险回归模型分析子宫内膜癌患者预后的影响因素。结果 观察组、对照组子宫内膜组织中TIPE2阳性率分别为28.33%、71.54%。与对照组相比，观察组子宫内膜组织TIPE2阳性率降低（P<0.05）；观察组、对照组子宫内膜组织中Ki67阳性率分别为33.33%、5.38%。观察组子宫内膜组织Ki67阳性率高于对照组（P<0.05）。对120例子宫内膜癌患者随访2年，至随访结束，93例患者存活，生存率77.50%。Cox模型分析结果显示，TIPE2阴性（HR=3.736，95% CI=1.016~13.157）为子宫内膜癌患者死亡的独立危险因素。此外，子宫内膜癌组织中TIPE2阴性与组织分级相关（P<0.001）。结论 TIPE2阴性是子宫内膜癌患者预后不良的独立危险因素，可作为评估子宫内膜癌不良预后的辅助指标。
英文摘要:
      Objective To investigate the expression of tumor necrosis factor-inducible protein 8-like protein 2(TIPE2) and proliferating nuclear antigen Ki67 in endometrial carcinoma tissue and their prognostic value. Methods From January 2018 to January 2020, 120 patients with endometrial cancer who were treated in gynecology of Affiliated Hospital of Hebei University of Engineering were selected as the observation group, and 130 patients with non-endometrial cancer treated in the same period were selected as the control group; all patients received surgical treatment, and the clinical and pathological data of patients were retrospectively collected. The expression levels of TIPE2 and Ki67 in the pathological tissues of the two groups were compared.Meanwhile, patients in the observation group were followed up regularly to analyze the two years survival, and the prognosis factors of endometrial cancer patients were analyzed by Cox proportional regression model.Results The positive rates of TIPE2 in the observation and control groups was 28.33% and 71.54%, respectively. Compared with the control group, the TIPE2 positive rate decreased significantly in the observation group(P<0.05).The positive rate of Ki67 was 33.33% and 5.38%, respectively.Compared with the control group, the positive rate of Ki67 increased significantly in the observation group(P<0.05).After two years of follow-up, 93 of the 12 patients survived, with a survival rate of 77.5%.For 120 patients with endometrial cancer for two years to the end of follow-up, 93 patients survived with a survival rate of 77.50%. The results of Cox risk model analysis showed that TIPE2-negative(HR=3.736,95%CI:1.016~13.157)was an independent risk factor for death in endometrial cancer patients. In addition, TIPE2 negative in endometrial cancer tissue was associated with tissue grade(P <0.001). Conclusions TIPE2-negative endometrial cancer cells increase the lymph node metastasis rate, and they are independent risk factors for poor prognosis of endometrial cancer patients and can be used as an adjuvant indicator to evaluate the prognosis of endometrial cancer.
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