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| 乳腺癌患者新辅助化疗期间认知水平与负性情绪的纵向研究 |
| A longitudinal study of cognitive level and negative emotion in breast cancer patients during neoadjuvant chemotherapy |
| 投稿时间：2023-07-11 |
| DOI：10.3969/j.issn.1000-0399.2024.05.020 |
| 中文关键词: 乳腺癌 新辅助化疗 认知水平 负性情绪 变化轨迹 |
| 英文关键词: Breast cancer Neoadjuvant chemotherapy Cognitive level Negative emotions Change trajectory |
| 基金项目:重庆市科卫联合医学科研项目面上项目（编号：2023MSXM103），重庆市沙坪坝区决策咨询与管理创新项目（编号：jcd202269），重庆市医药生物技术协会科研育苗项目（编号：cmba2022kyym-zkxmH0010） |
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| 中文摘要: |
| 目的 探讨乳腺癌患者新辅助化疗（NAC）期间认知水平与负性情绪变化轨迹并分析二者相关性。 方法 选取 2022年 8 月至 2023 年 1 月重庆大学附属肿瘤医院入院的 99 例乳腺癌患者，采用 FACT-Cog（Version 3）量表、词语流畅性测验、连线测验 A型、数字广度测试、焦虑自评量表、抑郁自评量表进行纵向调查，在 NAC 前（TP0）、行 NAC 第 1 周期后（TP1），手术前（TP2）动态评估患者的认知水平、情绪的变化，使用 Pearson 相关性分析二者之间的相关性。 结果 乳腺癌患者在 NAC 期间从 TP0～TP2 认知水平呈下降趋势（P＜0.05）；TP0～TP2 焦虑、抑郁水平呈先下降后上升趋势（P＜0.05）；Pearson 相关性分析结果显示，新辅助乳腺癌患者认知水平与焦虑、抑郁在 TP0 时期均呈负相关（r=-0.443、-0.446）；认知水平与焦虑、抑郁在 TP1 时期均呈负相关（r=-0.488、-0.522），认知水平与焦虑、抑郁在 TP2 时期均呈负相关（r=-0.580、-0.539）。 结论 乳腺癌患者 NAC 期间认知水平呈下降趋势，认知能力受负性情绪的影响。 |
| 英文摘要: |
| Objective To investigate thetrajectories of cognitive level and negative mood in Breast cancer patients at different stages of neoadjuvant chemotherapy, and to analyze the correlation between the two variables. Methods A longitudinal study was conducted to investigate 99 breast cancer patients admitted to Chongqing University Cancer Hospital in August 2022 to January 2023 by using the FACT-Cog (Version 3) scale, word fluency test, wiring test type A, numerical breadth test, anxiety self-rating scale, and depression self-rating scale to dynamically assesses changes in cognition and mood in NAC (TP0), after NAC Cycle 1 (TP1), before surgery (TP2), and the correlation between the two variables were analyzed. Results The cognitive level of TP0~TP2 decreased progressively during neoadjuvant chemotherapy (P<0.05), and the anxiety and depression levels of TP0~TP2 increased progressively (P<0.05),Pearson correlation analysis results showed that the cognitive level of neoadjuvant breast cancer patients was negatively correlated with anxiety and depression in the TP0 period (r=-0.443、-0.446), Cognitive level was negatively correlated with anxiety and depression during TP1 (r=-0.488、-0.522).Cognitive level was negatively correlated with anxiety and depression during TP2 (r=-0.580、-0.539). Conclusion Cognitive level of breast cancer patients during neoadjuvant chemotherapy has a tendency to decline;cognitive ability is affected by negative emotions. |
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