文章摘要
乳腺癌患者新辅助化疗期间认知水平与负性情绪的纵向研究
A longitudinal study of cognitive level and negative emotion in breast cancer patients during neoadjuvant chemotherapy
投稿时间:2023-07-11  
DOI:10.3969/j.issn.1000-0399.2024.05.020
中文关键词: 乳腺癌  新辅助化疗  认知水平  负性情绪  变化轨迹
英文关键词: Breast cancer  Neoadjuvant chemotherapy  Cognitive level  Negative emotions  Change trajectory
基金项目:重庆市科卫联合医学科研项目面上项目(编号:2023MSXM103),重庆市沙坪坝区决策咨询与管理创新项目(编号:jcd202269),重庆市医药生物技术协会科研育苗项目(编号:cmba2022kyym-zkxmH0010)
作者单位E-mail
罗羽 400030 重庆沙坪坝 重庆大学附属肿瘤医院乳腺肿瘤中心  
邓永春 400030 重庆沙坪坝 重庆大学附属肿瘤医院乳腺肿瘤中心  
周俸名 400030 重庆沙坪坝 重庆大学附属肿瘤医院乳腺肿瘤中心  
张欢 400030 重庆沙坪坝 重庆大学附属肿瘤医院乳腺肿瘤中心 39002956@qq.com 
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中文摘要:
      目的 探讨乳腺癌患者新辅助化疗(NAC)期间认知水平与负性情绪变化轨迹并分析二者相关性。 方法 选取 2022年 8 月至 2023 年 1 月重庆大学附属肿瘤医院入院的 99 例乳腺癌患者,采用 FACT-Cog(Version 3)量表、词语流畅性测验、连线测验 A型、数字广度测试、焦虑自评量表、抑郁自评量表进行纵向调查,在 NAC 前(TP0)、行 NAC 第 1 周期后(TP1),手术前(TP2)动态评估患者的认知水平、情绪的变化,使用 Pearson 相关性分析二者之间的相关性。 结果 乳腺癌患者在 NAC 期间从 TP0~TP2 认知水平呈下降趋势(P<0.05);TP0~TP2 焦虑、抑郁水平呈先下降后上升趋势(P<0.05);Pearson 相关性分析结果显示,新辅助乳腺癌患者认知水平与焦虑、抑郁在 TP0 时期均呈负相关(r=-0.443、-0.446);认知水平与焦虑、抑郁在 TP1 时期均呈负相关(r=-0.488、-0.522),认知水平与焦虑、抑郁在 TP2 时期均呈负相关(r=-0.580、-0.539)。 结论 乳腺癌患者 NAC 期间认知水平呈下降趋势,认知能力受负性情绪的影响。
英文摘要:
      Objective To investigate thetrajectories of cognitive level and negative mood in Breast cancer patients at different stages of neoadjuvant chemotherapy, and to analyze the correlation between the two variables. Methods A longitudinal study was conducted to investigate 99 breast cancer patients admitted to Chongqing University Cancer Hospital in August 2022 to January 2023 by using the FACT-Cog (Version 3) scale, word fluency test, wiring test type A, numerical breadth test, anxiety self-rating scale, and depression self-rating scale to dynamically assesses changes in cognition and mood in NAC (TP0), after NAC Cycle 1 (TP1), before surgery (TP2), and the correlation between the two variables were analyzed. Results The cognitive level of TP0~TP2 decreased progressively during neoadjuvant chemotherapy (P<0.05), and the anxiety and depression levels of TP0~TP2 increased progressively (P<0.05),Pearson correlation analysis results showed that the cognitive level of neoadjuvant breast cancer patients was negatively correlated with anxiety and depression in the TP0 period (r=-0.443、-0.446), Cognitive level was negatively correlated with anxiety and depression during TP1 (r=-0.488、-0.522).Cognitive level was negatively correlated with anxiety and depression during TP2 (r=-0.580、-0.539). Conclusion Cognitive level of breast cancer patients during neoadjuvant chemotherapy has a tendency to decline;cognitive ability is affected by negative emotions.
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