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| 类风湿性关节炎患者健康相关生命质量评价及其影响因素 |
| Assessmentof health-related quality of life and its influencing factors analysis in the inpatientswith rheumatoid arthritis based on EQ-5D-5L scale |
| 投稿时间：2023-10-24 |
| DOI：10.3969/j.issn.1000-0399.2024.06.022 |
| 中文关键词: 类风湿性关节炎 健康相关生命质量 健康效用值 欧洲五维度五水平健康量表 |
| 英文关键词: Rheumatoid arthritis Health-related quality of life Health utility index Quality of life five dimension five level scale |
| 基金项目:安徽省教育厅高校自然科学研究重点项目（编号：2022AH050653） |
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| 中文摘要: |
| 目的 探讨类风湿性关节炎（RA）住院患者健康相关生命质量（HRQoL）评分及其影响因素。 方法 采用欧洲五维度五水平健康量表（EQ-5D-5L）及自编问卷对 2023 年 4~9 月安徽中医药大学第一附属医院风湿免疫科收治的 200 例 RA 住院患者进行HRQoL 调查，EQ-5D-5L 量表中健康描述系统及视觉模拟标尺（EQ-VAS）分别用于测量 RA 患者健康效用值及整体健康状态，采用单因素分析、Tobit 多因素回归分析影响 RA 患者 HRQoL 的因素。 结果 共收集 190 份有效问卷，有效回收率 95%。RA 患者健康效用值为（0.77±0.25），EQ-VAS 评分为（76.44±43.65）分，其健康问题多集中于“行动能力”和“疼痛或不适”两个维度。Tobit 多因素回归分析显示，文化程度低（P=0.042，95%CI：0.032~0.143）与吸烟（P=0.013，95%CI：-0.154~-0.019）是 RA 患者 HRQoL 的危险因素。 结论 RA患者 HRQoL 与 EQ-VAS 较一般人群相比情况尚可，但仍存在健康效用值较低的问题，其中文化程度低与吸烟的患者 HRQoL 较差。 |
| 英文摘要: |
| Objective Todiscussthe health-related quality of life (HRQoL)in inpatients with rheumatoid arthritis (RA) and analyze its influencing factors. Methods From April to September 2023, the survey was conducted using the European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L) and a self-designed questionnaire on200 RA inpatientsat the Department of Rheumatology and Immunology in the First Affiliated Hospital of Anhui University of Traditional Chinese. The health description system and the European Quality Visual Analogue Scale (EQ-VAS)of EQ-5D-5Lwere used to measure the health utility and overall health status scores of RA patients, respectively. The influencing factors on HRQoL of RA patients were analyzed using t-test or One-way ANOVA, and Tobit regression model analysis was conducted to analyze the effects of basic information, clinical manifestations, and laboratoryindexesonHRQoL of RA patients. Results A total of 190 valid questionnaires were collected, with an effective recovery of 95%, the health utility value of RA patients was（0.77±0.25）, and the value of EQ-VASwas（76.44±43.65）. The health-related problems of RA patients mainly focused on the two dimensions of mobility and pain or discomfort. Tobit multivariable regression analysis showed that the lowerlevel of education（P=0.042，95%CI:0.032~0.143）and smoking（P= 0.013，95%CI:-0.154~-0.019）represented as risk factors affecting HRQoLin RA patients. Conclusions The overall HRQoL and EQ-VAS in RA patients are generally good as compared to the general population, but there are still problemswith lower health utility values. Patients with lower education levels and smoking habits have poorHRQoL. |
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