| Objective To explore the clinical value of serum interferon γ(IFN-γ), cystatin C (CYS-C) and fibrinogen (FIB) detection in peripheral blood of diabetic foot infection (DFI) patients with different severity and prognosis. Methods The clinical data of 92 patients with DFI admitted to the Maternal and Child Health Hospital of Gansu Province from February 2022 to February 2023 were retrospectively analyzed. Another 92 patients with diabetic foot (DF) who were not infected during the same period were selected as the control group (DF group). According to the infection severity of DFI patients, patients with mild and moderate infection were included in the mild to moderate infection group, and patients with severe infection were included in the severe infection group. Patients with DFI were followed up for three months. According to the difference in prognosis of DFI patients during the follow-up period, patients with healing were included in the good prognosis group, and patients with non-healing, amputation or death were included in the poor prognosis group.The levels of IFN-γ, CYS-C and FIB in peripheral blood were compared between different groups. Receiver operating characteristic (ROC) curve was used to analyze the predictive efficacy of IFN-γ, CYS-C and FIB levels in peripheral blood on the severity and prognosis of diabetic foot infection. Results The levels of IFN-γ, CYS-C and FIB in peripheral blood of DFI group were higher than those of DF group (t=6.460，5.325，8.051, P<0.05); the levels of IFN-γ, CYS-C and FIB in peripheral blood of severe infection group were higher than those of mild to moderate infection group (t=4.192，2.797，4.305, P<0.05); ROC curve analysis showed that the AUC of the combined diagnosis of DF patients with IFN- γ, CYS-C and FIB was 0.934, which was higher than that of IFN-γ (0.863), CYS-C (0.767) and FIB (0.838), and the difference was statistically significant (Z=3.047，5.232，3.749,P<0.05); the levels of IFN-γ, CYS-C and FIB in peripheral blood of the poor prognosis group were higher than those of the good prognosis group (t=3.071，2.392，3.771, P<0.05); ROC curve analysis showed that the prognosis AUC of IFN-γ, CYS-C and FIB combined diagnosis of DFI patients was 0.882, which was higher than 0.776 for IFN-γ, 0.667 for CYS-C and 0.780 for FIB, and the difference was statistically significant (Z=2.176，3.576，2.110, P<0.05). Conclusions The levels of IFN-γ, CYS-C and FIB in peripheral blood can effectively diagnose the severity of infection and poor prognosis of DFI patients, which can be used as a scientific basis for judging the severity of infection and prognosis. |
