| Objective To evaluate the clinical effect of platelet rich plasma（PRP） intra-articular injection combined with knee arthroscopic debridement on knee osteoarthritis（KOA）. Methods The clinical data of 108 patients with KOA who were treated in the Second Hospital of Qinhuangdao from May 2021 to may 2023 were collected. They were divided into a control group（receiving knee arthroscopic cleaning surgery） and a study group（receiving knee arthroscopic cleaning surgery combined with PRP intra-articular injection） according to different treatment methods, with 54 patients in each group. The preoperative and postoperative knee joint range of motion（KROM）, maximum knee flexion, Western Ontario and Mc Master University scores（WOMAC）, knee osteoarthritis severity index（ISOA）, visual analog scale（VAS） between two groups were compared, and the levels of joint fluid tumor necrosis factor alpha（TNF-α）, interleukin-1 β（IL-1β）, nitric oxide（NO）, and bone metabolism [osteoprotegerin（OPG）, cartilage oligomeric matrix protein（COMP）, matrix metalloproteinase-3（MMP-3）] were detected. Results Six months after surgery, the study group showed higher levels of KROM and maximum knee flexion compared to the control group. The study group exhibited lower levels of TNF-α, IL-1 β, and NO compared to the control group. The study group were lower than those in WOMAC, ISOA, and VAS compared to the control group. The difference in the above indicators between the two groups was statistically significant（all P＜0.05）. Five weeks after surgery, the study group exhibited lower levels of OPG compared to the control group, while COMP and MMP-3 were lower than those of the control group（all P＜0.05）. Compared with the control group, the difference in the above indexes before and after surgery was statistically significant（all P＜0.05）. Conclusion Arthroscopy combined with PRP intra-articular injection can improve knee joint function, inflammation levels and bone metabolism in patients with knee osteoarthritis. |
