| Objective To investigate the diagnostic value of serum stromal cell-derived factor-1（SDF-1） and soluble fms-like tyrosine kinase 1（sFlt-1） for preeclampsia. Methods From April 2022 to April 2024, 88 patients with preeclampsia who visited Wuhu First People′s Hospital were regarded as the preeclampsia group, including 52 cases in the mild preeclampsia group and 36 cases in the severe preeclampsia group. According to the gestational age of onset, they were separated into an early onset group of 39 cases and a late onset group of 49 cases. Meanwhile, 88 healthy pregnant women who underwent normal pregnancy tests in our hospital were as the control group. The serum levels of SDF-1, sFlt-1, and inflammatory factors tumor necrosis factor（TNF）-α, interleukin-6（IL-6）-6, and IL-12 were detected in all subjects. Pearson was applied to analyze the correlation between serum SDF-1, sFlt-1 and TNF-α, IL-6, IL-12 levels in patients with preeclampsia. Logistic regression was employed to analyze the factors affecting the occurrence of preeclampsia. Receiver operating characteristic（ROC） curve was used to analyze the diagnostic value of serum SDF-1 and sFlt-1 in preeclampsia. Results The serum levels of SDF-1, sFlt-1, TNF-α, IL-6 and IL-12 in the preeclampsia group were higher than those in the control group（t=6.533, 17.058, 12.251, 39.269, 11.752, P＜0.05）. The serum levels of SDF-1, sFlt-1, TNF-α, IL-6 and IL-12 in the early onset group were higher than those in the late onset group（t=2.319, 2.529, 8.109, 2.595, 2.635, P＜0.05）, and the serum levels in the severe preeclampsia group were higher than those in the mild preeclampsia group（t=1.999, 2.034, 3.094, 2.079, 3.397, P＜0.05）. The serum levels of SDF-1 and sFlt-1 in patients with preeclampsia were positively correlated with the levels of TNF-α, IL-6 and IL-12.（P＜0.05）. The serum SDF-1, sFlt-1, systolic blood pressure, diastolic blood pressure increase were risk factors for preeclampsia during pregnancy（P＜0.05）. The area under the curve（AUC） of the combined diagnosis of serum SDF-1, sFlt-1, systolic blood pressure and diastolic blood pressure for preeclampsia was higher than that of SDF-1, sFlt-1, systolic blood pressure and diastolic blood pressure alone diagnosis（Z=4.604, 4.842, 5.621, 5.429, P＜0.05）. Conclusion The serum levels of SDF-1 and sFlt-1 are elevated in patients with preeclampsia, and the combination of the two has high diagnostic value for preeclampsia. |
