| Objective To investigate the relationship between serum fibroblast growth factor 21（FGF21）, fatty acid binding protein 3（FABP3） and senile sarcopenia. Methods Eighty-three cases of senile sarcopenia in outpatient department from January to December 2023 were selected as the sarcopenia group, and eighty-five cases of senile health examination in outpatient department were selected as the control group. The risk factors of senile sarcopenia were analyzed by multiple logistic regression. Results Gender, age, body mass index, combined hypertension, combined diabetes, combined COPD, fasting blood glucose（FBG）, glycated hemoglobin（HbA1c）, hemoglobin（Hb）, white blood cells（WBC）, red blood cells（RBC）, total cholesterol（TC）, triacylglycerol（TC）, low density lipoprotein cholesterol（LDL-C） in both groups There were no significant differences in serum serum, high density lipoprotein cholesterol（HDL-C）, aspartate aminotransferase（ALT）, alanine aminotransferase（AST）, serum creatinine（Scr） and blood urea nitrogen（BUN）（P ＞ 0. 05）. The proportion of sarcopenia combined with coronary heart disease（24. 10%） was higher than that of control group（9. 41%）, and the levels of serum fibroblast growth factor 21（FGF21） and fatty acid binding protein 3（FABP3） were higher than those of control group, with statistical significance（P ＜ 0. 05）. Multiple Logistic regression analysis showed that combined coronary heart disease（OR=1. 452）, high FGF21 level（OR=1. 772）, and high FABP3 level（OR=1. 386） were independent risk factors for senile sarcopenia. Conclusion Serum levels of FGF21 and FABP3 in senile sarcopenia were significantly increased. Coronary heart disease, high levels of FGF21 and FABP3 were independent risk factors. |
