| Objective To compare the effects of alfentanil combined with remimazolam or propofol in hysteroscopy. Methods A total of 80 patients who underwent hysteroscopy in the Outpatient Operating Room of Meizhou People’s Hospital from the month of April 2022 to September of 2024 were selected and separated into group A（alfentanil combined with remimazolam） and group B（alfentanil combined with propofol） according to the random number table method, with 40 cases in each group. Group A was anesthetized with alfentanil combined with remimazolam, and group B with alfentanil combined with propofol intravenous anesthesia. The operation time, awakening time and awakening time of the two groups were compared. The systolic blood pressure（SBP）, diastolic blood pressure（DBP）, heart rate（HR） and blood oxygen saturation（SpO2） before, during and after the operation, as well as the modified awake sedation score（MOAA/S） at 1 min, 3 min and 5 min after the operation were observed in the two groups. The incidence of adverse reactions after surgery was compared between the two groups. Results The awakening time and lucid time of patients in Group A were both shorter than those in Group B（P＜0.05）. The excellent and good rate of anesthesia was 95.00%（38/40） in Group A and 90.00%（36/40） in Group B, with no statistically significant difference（P＞0.05）. The comparison of DBP, HR, and SpO2 values between two groups of patients at different time points showed statistically significant differences（P＜0.05）. SBP, DBP, HR, and SpO2 values all decreased first and then increased, and DBP, HR, and SpO2 values in group A were higher than those in group B（P＜0.05）; there was no statistically significant difference in SBP between the two groups（P＞0.05）. Different anesthesia methods and duration had an interactive effect on hemodynamic indicators（P＜0.05）. Overall, there was a significant difference in efficacy between the two groups, suggesting that different anesthesia methods and duration had an interactive effect on hemodynamic indicators（P＜0.05）. The results showed that with the increase of time, the MOAA/S scores of patients in both groups showed an increasing trend at different time points, and the difference was statistically significant（P＜0.05）. There was an interactive effect of different anesthesia methods and time on MOAA/S score（P＜0.05）. The incidence rates of respiratory depression and injection pain in Group A were both lower than those in Group B（P＜0.05）. Conclusion Alfentanil combined with remazolam anesthesia effect is similar to that of propofol, which can maintain the hemodynamic stability of hysteroscopy patients, and the time for patients to regain consciousness is short, with better safety, thus it can be safely and effectively applied to hysteroscopy. |
