| Objective To analyze the changes and significance of thyroid-related hormones in children with central precocious puberty before and after treatment with gonadotropin-releasing hormone analog (GnRHa). Methods A hundred children with central precocious puberty who received GnRHa treatment in Fudan University Affiliated Pediatric Hospital Anhui Hospital from May 2021 to October 2023 were selected as the research objects, and the levels of sex hormones, thyroid-related hormones, growth and changes of reproductive organs were observed and recorded before and after treatment. Pearson correlation analysis was used to analye the relationship between the changes of thyroid-related hormone levels and serum estrogen levels before and after GnRHa treatment. Results After treatment, the levels of FSH, LH, TSH, FT3 and FT4 were lower than those before treatment, and with the progress of treatment, the levels gradually became normal (P<0.05). The volume of uterus, ovary or testis decreased after GnRHa treatment, but there was no significant difference before and after treatment (P>0.05). Compared with before treatment, BMI and BA/CA decreased significantly after treatment, and the level changes gradually became normal with the progress of treatment (P<0.05). Serum TSH levels were positively correlated with LH levels before treatment, 3 months and 6 months after treatment (r=0.459, P<0.001; r=0.576, P<0.001; r=0.581, P<0.001), FSH level before treatment was positively correlated with BMI and BA/CA (r=0.594, P<0.001; r=0.586, P<0.001). Conclusion After treatment with GnRHa, the levels of serum sex hormones and thyroid-related hormones in children with central precocious puberty decrease significantly, and their growth and development gradually became normal. TSH may be used as a reference index for evaluating the curative effect of GnRHa. |
