| Objective To explore the correlation between changes in nutritional status during chemotherapy for colorectal cancer and cancer-related fatigue. Methods A total of colorectal cancer patients admitted to the First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People’s Hospital) from January 2023 to August 2024 were selected. The subjective global nutritional status assessment (PG-SGA) was used to evaluate the nutritional status of patients before, during, and after chemotherapy. A latent category trajectory model (LCTM) was constructed to group the trajectory of nutritional status changes. In the later stage of chemotherapy, the cancer-related fatigue self-assessment scale (CRF) was used to evaluate the symptoms of cancer-related fatigue in patients, and the incidence of cancer-related fatigue was recorded. Logistic regression analysis was used to investigate the relationship between the trajectory of nutritional status changes and cancer-related fatigue. Results ① The total PG-SGA scores of 186 colon cancer patients before, during, and after chemotherapy were (4.37 ± 0.31) points, (4.38 ± 0.30) points, (5.46 ± 0.33) points, and (6.50 ± 0.42) points, respectively. After LCTM screening, three classification trajectories were determined as the optimal models, namely low stable decreasing group, medium slow increasing group, and high rapid increasing group. There were statistically significant differences (P<0.05) in age, TNM stage, differentiation degree, long-term bed rest, CRF total score, and incidence of cancer-related fatigue among the three groups After adjusting for age, TNM staging, differentiation degree, and long-term bed rest, the risk of cancer-related fatigue increased by 1.500 times and 4.011 times in the moderate slow rise group and high rapid rise group, respectively, compared to the low stable decrease group (P<0.05), and the risk of cancer-related fatigue increased with the increase of PG-SGA total score (χ2 trend=146.728, P＜0.05）. Conclusion The nutritional status of colorectal cancer patients during chemotherapy is poor, and it shows an increasing trend with the prolongation of chemotherapy cycles, and is linearly correlated with cancer-related fatigue. It is necessary to actively carry out nutritional support to reduce cancer-related fatigue. |
