| Objective To explore the relationship between olfactory function and eosinophils and systemic immune inflammatory index in patients with chronic sinusitis after functional endoscopic sinus surgery. Methods A retrospective study was conducted to the collected clinical data of 292 patients with CRS who underwent FESS in our hospital from October 2022 to March 2024, and the patients were divided into outcome group (n=220) and non-outcome group (n=72) according to the results of olfactory function review three months after surgery. General data of the two groups of patients were compared. The risk factors affecting olfactory function outcome were analyzed by binary Logistic regression equation. Correlation was analyzed using Spearman correlation analysis. The receiver operating curve (ROC) was plotted, and the predictive value was evaluated using the area under the ROC curve (AUC value). Results The proportion of allergic rhinitis in the non-outcome group was higher, the postoperative scores of nasal endoscopy and olsniff endoscopy (Lund-Kennedey) were higher, and the levels of EOS, SII and C-reactive protein (CRP) were all higher than those in the outcome group (P<0.05). EOS(OR=1.359, 95%CI：1.005～ 1.838), SII(OR=1.128, 95%CI：1.059～1.201), CRP(OR=3.512, 95%CI:1.604～7.686) were all risk factors affecting the outcome of olfactory function (P<0.05). EOS, SII and CRP levels were positively correlated with the outcome of olfactory function (P<0.05). The AUC value of the combined diagnosis was 0.983(95%CI: 0.977～1.000), the sensitivity was 95.80%, the specificity was 95.50%, and the maximum approximate entry index was 0.983 (P<0.05). Conclusion The outcomes of olfactory function in CRS patients after FESS are related to EOS and SII levels, and when combined with CRP, they can predict postoperative olfactory function outcomes. |
