文章摘要
术前钼靶X线和磁共振检查及外泌体ctDNA水平与TNBC术后复发的关联研究
Study on the correlation between preoperative mammography, magnetic resonance imaging, extracellular vesicle ctDNA levels and postoperative recurrence of TNBC
投稿时间：2025-10-15  修订日期：2026-05-31
DOI：
中文关键词: 钼靶X线  磁共振  外泌体循环肿瘤DNA  三阴性乳腺癌  复发  影响因素
英文关键词: Molybdenum target X-ray  Magnetic resonance imaging  Extracellular vesicle circulating tumor DNA  Triple negative breast cancer  Recurrence  influence factor
基金项目:廊坊市科学技术研究与发展计划 2022013124
作者单位邮编
于亚男* 河北中石油中心医院 065000
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中文摘要:
      【】目的 探讨术前钼靶X线和磁共振(MRI)检查及外泌体循环肿瘤DNA(ctDNA)水平与三阴性乳腺癌(TNBC)术后复发的关联。方法 选取2020年7月至2022年7月在我院治疗的TNBC患者126例,所有患者均随访3年,其中术后复发患者43例,未复发患者83例。比较术后复发和未复发患者临床基线资料,术前钼靶X线及MRI参数、外泌体ctDNA水平差异,分析术后复发的影响因素。结果 术后复发患者TNM分期Ⅲ比例为48.84%,高于未复发患者(P＜0.05)；术后复发患者术前钼靶X线参数:无钙化、有腋窝淋巴结受累比例分别为88.37%和48.84%,MRI参数:病灶高信号、环状强化比例分别为58.14%和48.84%,均高于未复发患者(P＜0.05)。术后复发患者术前外泌体ctDNA水平为(640.30±83.30)ng/ml,高于未复发患者(P＜0.05)。Logistic回归分析显示:TNM分期、钼靶X线参数钙化、钼靶X线参数腋窝淋巴结受累、MRI参数病灶高信号、MRI参数环状强化和外泌体ctDNA水平是TNBC患者术后复发的影响因素(P＜0.05)。结论 术前钼靶X线、MRI参数及外泌体ctDNA水平变化与TNBC术后复发具有关联,临床治疗前应加以重视。
英文摘要:
      Objective: To investigate the relationship between preoperative molybdenum target X-ray and magnetic resonance (MRI), the level of tumor DNA in the exocrine circulation (ctDNA) and postoperative recurrence of triple negative breast cancer (TNBC). Methods: 126 TNBC patients treated in our hospital from July 2020 to July 2022 were selected, including 43 patients with postoperative recurrence and 83 patients without recurrence. The differences in clinical baseline data, mammography and MRI parameters, and extracellular vesicle ctDNA levels between patients with and without postoperative recurrence were compared, and the influencing factors of postoperative recurrence were analyzed. Results: The proportion of postoperative recurrent patients with TNM stage III was 48.84%, which was higher than that of non recurrent patients (P<0.05). Preoperative mammography parameters for patients with postoperative recurrence showed that the proportion of patients without calcification and with axillary lymph node involvement was 88.37% and 48.84%, respectively. MRI parameters showed that the proportion of high signal and circular enhancement lesions was 58.14% and 48.84%, respectively, which was higher than that of non recurrent patients (P<0.05). The preoperative level of extracellular vesicle ctDNA in patients with postoperative recurrence was (640.30 ± 83.30) ng/ml, which was higher than that in patients without recurrence (P<0.05). Logistic regression analysis showed that TNM staging, calcification, axillary lymph node involvement, high signal intensity of lesions, circular enhancement, and extracellular vesicle ctDNA were the influencing factors of postoperative recurrence in TNBC patients (P<0.05). Conclusion: Preoperative mammography, MRI parameters, and extracellular vesicle ctDNA levels are influencing factors for postoperative recurrence of TNBC, and should be taken seriously before clinical treatment.
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