|
| 晚期非小细胞肺癌抗血管生成治疗期间血脂动态与疗效预后 |
| Association between changes in lipid profiles and treatment efficacy as well as prognosis in anti-angiogenic therapy for advanced non-small cell lung cancer |
| 投稿时间：2025-03-11 |
| DOI：10.3969/j.issn.1000-0399.2025.11.004 |
| 中文关键词: 非小细胞肺癌 三酰甘油 总胆固醇 低密度脂蛋白 抗肿瘤治疗 抗血管生成治疗 疗效 |
| 英文关键词: Non-small cell lung cancer Triglyceride Total cholesterol Low-density lipoprotein Anti-tumor treatment Anti-angiogenic treatment Treatment efficacy |
| 基金项目:安徽省肿瘤医院青年基金(编号:2023YJQN004,2020YJQN018) |
|
| 摘要点击次数: 1810 |
| 全文下载次数: 177 |
| 中文摘要: |
| 目的 分析晚期非小细胞肺癌（NSCLC）患者接受抗血管生成药物联合治疗前后血清血脂水平变化，探索抗血管生成药物对脂质代谢的影响及其在疗效预后监测中的临床价值。方法 回顾性分析2020年3月至2022年5月在中国科学技术大学附属第一医院西区（安徽省肿瘤医院）就诊的77例晚期NSCLC患者的临床资料，根据治疗方式不同分为联合抗血管生成治疗组（n=48）和非联合抗血管治疗组（n=29）。比较两组患者治疗前后血清总胆固醇（TC）、三酰甘油（TG）及低密度脂蛋白（LDL-C）水平变化；48例联合抗血管生成治疗患者根据血脂异常标准分为高值组和正常组，Cox比例风险回归模型分析治疗后血脂水平与疗效及预后的相关性，Kaplan-Meier分析血脂水平与无进展生存期（PFS）的关系。结果 联合抗血管治疗组治疗前后TG、TC和LDL-C水平差值高于非抗血管治疗组，两组之间TG、TC和LDL-C差值均有统计学意义（P<0.05）。48例抗血管联合治疗患者中，血脂高值组患者疾病控制率（DCR）高于正常组患者（100.00%比95.24%），差异无统计学意义（P>0.05）；疾病缓解率（ORR）高于正常组患者（66.67%比38.01%），差异有统计学意义（P<0.05）;Cox回归分析显示治疗后TG、TC和LDL-C增高是预后的保护因素（HR=0.352、0.013、0.355;P=0.004、0.230、0.043）;Kaplan-Meier法分析显示TC和LDL-C高值组的中位PFS均长于正常组（χ2=4.445,P=0.014；χ2=5.550,P=0.018）,TG高值组和正常组PFS比较，差异无统计学意义（χ2=0.965,P=0.326）。结论 晚期NSCLC患者受抗血管生成药物联合治疗后TG、TC和LDL-C血脂水平升高；治疗后血脂升高患者可获得更好的抗肿瘤疗效。 |
| 英文摘要: |
| Objective To analyze the changes in serum lipid levels before and after combined treatment with anti angiogenic drugs in patients with advanced non-small cell lung cancer, in order to explore the effects of anti angiogenic drugs on lipid metabolism and their clinical value in monitoring therapeutic efficacy and prognosis. Methods A retrospective analysis was conducted on the clinical data of 77 patients with advanced non-small cell lung cancer（NSCLC） who visited the First Affiliated Hospital of the University of Science and Technology of China from March 2020 to May 2022. According to different treatment methods, they were divided into a combined anti-angiogenic therapy group（n=48） and a noncombined anti-angiogenic therapy group（n=29）. The changes in serum total cholesterol（TC）, triglycerides（TG）, and low-density lipoprotein（LDL-C） levels between two groups of patients were compared before and after treatment. Results Forty-eight patients undergoing combined anti-angiogenic therapy were divided into a high-value group and a normal group according to the criteria for abnormal blood lipids. Cox proportional hazards regression model was used to analyze the correlation between post-treatment blood lipid levels, efficacy, and prognosis. Kaplan Meier analysis was used to examine the relationship between blood lipid levels and SPF. The difference in TG, TC, and LDL-C levels before and after treatment in the combined anti-vascular treatment group was more evident than that in the non antivascular treatment group. There was a statistically significant difference in TG, TC and LDL-C levels between the two groups before and after treatment（P＜0.05）. Among the 48 patients receiving combined anti-vascular therapy, the disease control rate（DCR） and objective response rate（ORR） of the high blood lipid group were 100.00% and 66.67%, respectively, which were higher than those of the normal group（95.24% and 38.01%）, the difference of DCR was not statistically significant, but the difference of ORR was statistically significant. Elevated levels of TG, TC, and LDL-C after treatment were protective factors for prognosis（HR=0.352, 0.013, 0.355; P=00.004, 0.230, 0.043）; Kaplan Meier analysis showed no statistically significant difference in PFS between the high TG group and the normal group（χ2=0.965, P=00.326）, while the median PFS of the high TC and LDL-C groups was longer than that of the normal group（χ2=4.445, P=00.014; χ2=5.550, P=00.018）. Conclusion After combined treatment with anti angiogenic drugs, the levels of TC, TG, and LDL-C blood lipids in patients with advanced NSCLC significantly increase; Patients with elevated blood lipids after treatment can achieve better anti-tumor efficacy, and elevated TC and LDL-C are significantly correlated with longer PFS. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
