| Objective To explore the effect of reduced glutathione（GSH） combined with polyene phosphatidylcholine in the treatment of sepsis-related liver injury, and analyze its impact on liver function and serological indicators. Methods A retrospective analysis was conducted on the data of 102 patients with sepsis-related liver injury at Yuncheng Central Hospital Affiliated to Shanxi Medical University from January 2021 to September 2023. According to different treatment plans, they were divided into a study group and a control group, with 51 patients in each group. Both groups received symptomatic treatment for sepsis. On this basis, the control group was given polyene phosphatidylcholine, while the study group was given GSH combined with polyene phosphatidylcholine, with continuous treatment for 14 d. The therapeutic effects and adverse reactions of the two groups were compared, as well as the disease scores [acute physiology and chronic health evaluation system II（APACHE II） score, degree of liver injury（Child-Pugh） score], blood routine indicators, liver function indicators, and serological indicators [interleukin-6（IL-6）, D-dimer（D-D）, N-terminal pro-brain natriuretic peptide（NT-proBNP）] levels before and after treatment. Results The total effective rate of the study group was higher than that of the control group（P＜0.05）. After treatment, the APACHE II score, Child-Pugh score, WBC, NLR, and PLR levels in the study group were lower than those in the control group, and the serum AST, ALT, GGT, TBIL, IL-6, D-D, and NT-proBNP levels were lower than those in the control group, with statistically significant differences（P＜0.05）. The differences in the aforementioned indicators before and after treatment were statistically significant（P＜0.05）.There was no statistically significant difference in the incidence of adverse reactions between the two groups（P＞0.05）. Conclusion The combination of GSH and polyene phosphatidylcholine in the treatment of patients with sepsis-related liver injury can enhance clinical efficacy, improve clinical symptoms and liver function, inhibit inflammatory response, and alleviate hypercoagulability, reduce myocardial injury, slow down disease progression, and maintain a certain level of safety. |
