|
| 血清CTRP3 IGF-1与牙周炎患者正畸治疗预后的关系 |
| Relationship between serum CTRP3, IGF-1 and orthodontic treatment prognosis in patients with periodontitis |
| 投稿时间：2025-02-10 |
| DOI：10.3969/j.issn.1000-0399.2025.12.009 |
| 中文关键词: 牙周炎 C1q/TNF相关蛋白3 胰岛素样生长因子-1 正畸治疗 预后 |
| 英文关键词: Periodontitis C1q/TNF related protein 3 Insulin-like growth factor-1 Orthodontic treatment Prognosis |
| 基金项目: |
|
| 摘要点击次数: 845 |
| 全文下载次数: 162 |
| 中文摘要: |
| 目的 探究血清C1q/TNF相关蛋白3（CTRP3）、胰岛素样生长因子-1（IGF-1）与牙周炎患者正畸治疗预后的关系。方法 选取2020年4月至2024年4月太原市中心医院口腔科收治的110例牙周炎患者作为疾病组，依据复查结果分为预后良好组（n=68）及预后不良组（n=42），同期120例牙周健康志愿者作为对照组。采用酶联免疫吸附法（ELISA）检测血清CTRP3、IGF-1水平，比较预后良好组与预后不良组患者临床资料及血清CTRP3、IGF-1水平，多因素logistic回归分析牙周炎患者预后不良的影响因素，绘制受试者工作特征（ROC）曲线分析血清CTRP3、IGF-1水平对牙周炎患者不良预后的预测价值。结果 疾病组血清CTRP3、IGF-1水平低于对照组（P<0.05），预后不良组血清CTRP3、IGF-1水平低于预后良好组（P<0.05），患牙最深[牙周袋深度（PD）]值及牙根形态异常人数高于预后良好组（P<0.05），血清CTRP3（OR=0.454, 95%CI:0.344～0.600）、IGF-1（OR=0.332,95%CI:0.217～0.508）水平是牙周炎患者不良预后的保护因素（P<0.05），联合利用CTRP3与IGF-1预测牙周炎患者预后不良的价值[曲线下面积（AUC）=0.931,95%CI:0.866～0.970]高于单独检测CTRP3（AUC=0.870,95%CI:0.792～0.926）、IGF-1（AUC=0.879,95%CI:0.803～0.934），差异具有统计学意义(Z联合-CTRP3=2.674、Z联合-IGF-1=2.119,P<0.05)。结论 牙周炎正畸治疗后预后不良患者血清CTRP3、IGF-1水平低于预后良好患者，联合检测对牙周炎患者不良预后的预测价值较高。 |
| 英文摘要: |
| Objective To investigate the relationship between serum C1q/TNF related protein 3（CTRP3）, insulin-like growth factor-1（IGF-1） and orthodontic treatment prognosis in patients with periodontitis. Methods Totally 110 patients with periodontitis admitted to the Department of Stomatology at Taiyuan Central Hospital from April 2020 to April 2024 were regarded as the disease group. Complying with the follow-up results, they were assigned into a good prognosis group（n=68） and a poor prognosis group（n=42）, with 120 periodontal health volunteers in the same period as the control group. ELISA method was used to detect serum CTRP3 and IGF-1. The clinical data and serum CTRP3 and IGF-1 were compared between good prognosis group and poor prognosis group. Multivariate logistic regression was used to analyze the influencing factors of poor prognosis in patients. The predictive value of serum CTRP3 and IGF-1 levels for poor prognosis in patients was analyzed by drawing ROC curves. Results Serum CTRP3 and IGF-1 levels were lower in the disease group than in the control group（P ＜0.05）. Serum CTRP3 and IGF-1 levels were lower in the poor prognosis group than in the good prognosis group（P ＜0.05）, and the deepest value of the affected teeth [periodontal probing depth（PD）] and the number of abnormal tooth root morphology were higher than those in the good prognosis group（P ＜0.05）. The serum CTRP3 [OR（95%CI）=0.454（0.344～0.600）] and IGF-1 [OR（95%CI） =0.332（0.217～0.508）] were protective factors for poor prognosis in patients（P ＜0.05）. The value of the combined use of CTRP3 and IGF-1 in predicting poor prognosis in patients（AUC=0.931） was higher than that of the separate testing of CTRP3（AUC=0.870） and IGF-1（AUC=0.879）, and the difference was statistically significant(Zcombined-CTRP3=2.674, Zcombined-IGF-1=2.119, P ＜0.05). Conclusion The serum CTRP3 and IGF-1 in patients with poor prognosis after orthodontic treatment for periodontitis are lower than those in patients with good prognosis. Combined monitoring has a high predictive value for poor prognosis in patients with periodontitis. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
