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| 血清外泌体hsa＿circ＿0052513 circSATB2与非小细胞肺癌根治术后化疗效果的关系 |
| Relationship between serum exosomes hsa＿circ＿0052513 and circSATB2 andeffect of chemotherapy after radical surgery for non-small cell lung cancer |
| 投稿时间：2025-04-07 |
| DOI：10.3969/j.issn.1000-0399.2026.01.009 |
| 中文关键词: 环状RNA_0052513 环状RNA SATB2 非小细胞肺癌根治术 化疗 |
| 英文关键词: Ring RNA＿0052513 Circular RNA SATB2 Radical surgery for non-small cell lung cancer Chemotherapy |
| 基金项目:河北省2023年度医学科学研究课题(编号:20231340) |
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| 中文摘要: |
| 目的 探究血清外泌体环状RNA＿0052513(hsa＿circ＿0052513)、环形RNA特异AT序列结合蛋白2(circSATB2)对非小细胞肺癌根治术后化疗效果的评估价值。方法 选取2022年1月至2023年4月期间中国人民解放军联勤保障部队第九八〇医院检验科收治的165例行非小细胞肺癌根治术患者，根据疗效不同分为治疗有效组（n=134）和治疗无效组（n=31），另将同期健康体检者作为对照组（n=132）。对比3组血清hsa＿circ＿0052513、circSATB2水平并采用多因素logistic回归分析、Spearman相关性分析和受试者工作特征（ROC）曲线分析上述指标与非小细胞肺癌根治术治疗效果的关系。结果 与治疗无效组相比，治疗有效组TNM分期、吸烟史、hsa＿circ＿0052513、circSATB2差异有统计学意义（P<0.05）。多因素分析显示，TNM分期Ⅳ期、血清hsa＿circ＿0052513水平高、有吸烟史、血清circSATB2水平高均为治疗无效的危险因素；Spearman相关性分析显示，血清circSATB2、hsa＿circ＿0052513水平与化疗效果呈负相关（r=-0.382、-0.394,P均<0.001）;ROC曲线显示，circSATB2与hsa＿circ＿0052513联合检测预测（AUC=0.765,95CI:0.657～0.874）价值较circSATB2、hsa＿circ＿0052513单独预测更高（Z=2.452,P=0.014;Z=2.890,P=0.004）。结论 行非小细胞肺癌根治术患者血清circSATB2、hsa＿circ＿0052513水平升高，提示术后化疗效果较好。 |
| 英文摘要: |
| Objective To investigate the value of serum exosomal circular RNA＿0052513(hsa＿circ＿0052513), and circular RNAspecific AT sequence binding protein 2(circSATB2) in assessing the efficacy of chemotherapy after radical surgery for non-small cell lung cancer. Methods A total of 165 patients with non-small cell lung cancer radical surgery in our hospital were selected between January 2022 and April 2023, and divided into 134 cases of treatment effective group and 31 cases of treatment ineffective group according to the different efficacy. Another 132 cases who had health checkups in the same period were taken as the control group. Hsa＿circ＿0052513, circSATB2 levels were compared. Multifactorial logistic, Spearman, and subject work characteristics(ROC) were used to analyze the relationship between the above indexes and treatment ineffectiveness. Results TNM stage, hsa＿circ＿0052513, smoking history, and circSATB2 were higher in the treatment ineffective group than in the treatment effective group(P<0.05). Multifactorial showed that all of the above were risk factors for treatment ineffectiveness. Spearman showed that circSATB2, hsa＿circ＿0052513 were negatively correlated with chemotherapeutic efficacy, and ROC showed that the combination of the two had high predictive value(AUC=0.765,95 CI:0.657～0.874). Conclusion Elevated levels of circSATB2 and hsa＿circ＿0052513 in patients undergoing radical surgery for non-small cell lung cancer can be used to assess the efficacy of postoperative chemotherapy. |
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