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| 血清TSAT IL-6水平与缺铁性贫血患儿疾病严重程度的关系及预测价值分析 |
| Analysis of the relationship between serum TSAT and IL-6 levels and the severity of iron deficiency anemia in children and their predictive value |
| 投稿时间：2025-02-11 |
| DOI：10.3969/j.issn.1000-0399.2026.01.010 |
| 中文关键词: 转铁蛋白饱和度 白细胞介素-6 儿童 缺铁性贫血 疾病严重程度 |
| 英文关键词: Transferrin saturation Interleukin-6 Children Iron deficiency anemia Severity of disease |
| 基金项目:河北省2024年度医学科学研究课题计划项目(编号:20241742) |
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| 中文摘要: |
| 目的 分析血清转铁蛋白饱和度（TSAT）、白细胞介素-6(IL-6)水平与缺铁性贫血患儿疾病严重程度的关系及其预测价值。方法 选取2023年9月至2024年9月沧州市中心医院儿内五科收治的缺铁性贫血儿童91例作为观察组，同期体检健康儿童85例作为对照组；采用ELISA法检测研究对象血清IL-6表达水平；采用全自动生化分析仪检测血清TSAT水平；采用Pearson法分析血清TSAT、IL-6水平相关性，logistic回归分析发生缺铁性贫血的影响因素，ROC曲线评估血清TSAT、IL-6水平预测儿童发生缺铁性贫血的效能。结果 缺铁性贫血患儿血红蛋白（Hb）、红细胞计数（RBC）、红细胞压积（HCT）、血清铁蛋白（SF）、TSAT水平均低于健康儿童（P<0.05）,IL-6水平均高于健康儿童（P<0.05）；缺铁性贫血患儿血清TSAT、IL-6水平呈负相关（P<0.001）；不同病情程度患儿间极重度贫血组TSAT最低、IL-6最高（P<0.05）；高水平IL-6是儿童发生缺铁性贫血的独立危险因素（OR=2.155,95%CI:1.378～3.369），高水平Hb(OR=0.716,95%CI:0.519～0.987)、RBC(OR=0.815,95%CI:0.666～0.997)、HCT(OR=0.732,95%CI:0.570～0.941)、SF(OR=0.744,95%CI:0.562～0.985)、TSAT(OR=0.657,95%CI:0.522～0.826)是保护因素（P<0.05）；血清TSAT、IL-6单独及联合预测儿童发生缺铁性贫血的曲线下面积（AUC）分别为0.830(95%CI:0.767～0.883)、0.808(95%CI:0.742～0.864)、0.884(95%CI:0.827～0.927)，联合预测效能更佳（P<0.05）。结论 血清TSAT、IL-6水平与缺铁性贫血患儿疾病严重程度相关，其血清表达水平对儿童缺铁性贫血有一定预测价值，二者联合预测效能更好。 |
| 英文摘要: |
| Objective To analyze the relationship between serum transferrin saturation(TSAT), interleukin-6(IL-6) levels, and the severity of iron deficiency anemia in children, and their predictive value. Methods From September 2023 to September 2024, 91 children with iron deficiency anemia who visited our hospital were included as the observation group, and meantime, 85 healthy children who experienced physical check ups were included as the control group. ELISA method was applied to detect the expression level of serum IL-6. Fully automated biochemical analyzer was applied to detect serum TSAT level. Pearson method was applied to analyze the correlation between serum TSAT and IL-6 levels. Logistic regression was applied to analyze the factors associated with iron deficiency anemia. ROC curve was applied to analyze the efficacy of serum TSAT and IL-6 levels in predicting iron deficiency anemia in children. Results The levels of Hb, RBC, HCT, SF, and TSAT in children with iron deficiency anemia were unusually lower than those in healthy children(P<0.05), and the level of IL-6 was obviously higher than that in healthy children(P<0.05). The levels of serum TSAT and IL-6 were negatively correlated(P<0.001). There were obvious differences in serum TSAT and IL-6 levels among children with different severity of disease, with the lowest TSAT and highest IL-6 in the extremely severe anemia group(OR=2.155,95%CI:1.378～3.369). High level of IL-6 was an independent risk factor for iron deficiency anemia in children(P<0.05), while high levels of Hb(OR=0.716,95%CI:0.519～0.987)、RBC(OR=0.815,95%CI:0.666～0.997)、HCT(OR=0.732,95%CI:0.570～0.941)、SF(OR=0.744,95%CI:0.562～0.985) and TSAT(OR=0.657,95%CI:0.522～0.826) were protective factors(P<0.05). The area under the curve(AUC) of serum TSAT and IL-6 alone and in combination for predicting iron deficiency anemia in children was 0.830(95%CI:0.767～0.883)、0.808(95%CI:0.742～0.864) and 0.884(95%CI:0.827～0.927), respectively, and the combined prediction was more effective(P<0.05). Conclusion The levels of serum TSAT and IL-6 are correlated with the severity of iron deficiency anemia in children, and have certain predictive value for iron deficiency anemia in children. The combined predictive power of the two is better. |
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