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| 急性脑梗死患者血清ZAG 3-NT HDAC6水平与血管性认知障碍的相关性 |
| Correlation between serum ZAG, 3-NT, HDAC6 and vascular cognitive impairment in patients with acute cerebral infarction |
| 投稿时间：2025-04-12 |
| DOI：10.3969/j.issn.1000-0399.2026.02.010 |
| 中文关键词: 急性脑梗死 血管性认知障碍 锌α2糖蛋白 3-硝基酪氨酸 组蛋白去乙酰化酶6 |
| 英文关键词: Acute cerebral infarction Vascular cognitive impairment Zinc alpha 2 glycoprotein 3-nitrotyrosine Histone deacetylase 6 |
| 基金项目:宿迁市科技局科研专项支撑项目(编号:SY202211) |
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| 中文摘要: |
| 目的 探究急性脑梗死（ACI）患者血清锌α2糖蛋白（ZAG）、3-硝基酪氨酸（3-NT）、组蛋白去乙酰化酶6（HDAC6）水平与血管性认知障碍（VCI）的相关性。方法 选取2023年1月至2024年11月在江苏省人民医院宿迁医院住院的ACI患者204例，根据是否发生VCI将其分为VCI组（n=79）和无认知障碍（NCI）组（n=125）。采用酶联免疫吸附法（ELISA）测定两组患者血清ZAG、3-NT、HDAC6表达水平；Spearman秩相关分析血清ZAG、3-NT和HDAC6与蒙特利尔认知评估量表（MoCA）评分的关系。采用logistic分析影响VCI的因素；采用受试者工作特征（ROC）曲线分析血清ZAG、3-NT、HDAC6水平对VCI的诊断价值。结果 NCI组与VCI组MoCA评分、Fazekas评分差异有统计学意义（P<0.05）。与NCI组相比，VCI组血清ZAG水平降低（P<0.05）,3-NT、HDAC6水平增加（P<0.05）。ACI患者血清ZAG水平与MoCA评分呈正相关（rs=0.465,P<0.05），血清3-NT、HDAC6水平与MoCA评分呈负相关（rs=-0.438,-0.459,P<0.05）。血清ZAG为VCI的保护因素，3-NT、HDAC6为VCI的危险因素（P<0.05）。ZAG、3-NT、HDAC6 3者联合诊断VCI的曲线下面积（AUC）较高，优于单一指标诊断(Z3者联合-ZAG=5.102,P<0.001;Z3者联合-3-NT=4.976,P<0.001;Z3者联合-HDAC6=4.712,P<0.001)，灵敏度为87.34%，特异度为93.60%。结论 VCI患者血清ZAG低表达，3-NT、HDAC6高表达，与MoCA评分密切相关，3者联合对VCI具有较高诊断价值。 |
| 英文摘要: |
| Objective To investigate the correlation between serum zinc alpha 2 glycoprotein（ZAG）, 3-nitrotyrosine（3-NT）, histone deacetylase 6（HDAC6） and vascular cognitive impairment（VCI） in patients with acute cerebral infarction（ACI）. Methods In this study, 204 patients with ACI hospitalized in our hospital from January 2023 to November 2024 were prospectively selected and divided into the VCI group and NCI group based on whether they developed VCI. Enzyme linked immunosorbent assay（ELISA） was used to measure serum ZAG, 3-NT, and HDAC6. Spearman correlation was used to analyze the relationship between serum ZAG, 3-NT, HDAC6 and Montreal Cognitive Assessment（MoCA） score. Logistic method was used to analyze the factors that affected VCI. Receiver operating characteristic（ROC） curve was used to analyze the diagnostic value of serum ZAG, 3-NT, and HDAC6 for VCI. Results The MoCA score, Fazekas score was statistically different between the NCI group and the VCI group（P<0.05）. Compared with NCI group, the serum ZAG in VCI group was prominently lower（P<0.05）, while 3-NT and HDAC6 were prominently higher（P<0.05）. The serum ZAG in ACI patients was positively correlated with MoCA score（rs=0.465, P<0.05）, while serum 3-NT and HDAC6 were negatively correlated with MoCA score（rs=-0.438,-0.459, P<0.05）. Serum ZAG was a protective factor for VCI, while 3-NT and HDAC6 were risk factors for VCI（P<0.05）. The area under the curve（AUC） of the combined diagnosis of serum ZAG, 3-NT, and HDAC6 for VCI was the highest, which was superior to single diagnosis(Zcombination-ZAG=5.102, P<0.001; Zcombination-3-NT=4.976, P<0.001; Zcombination-HDAC6=4.712, P<0.001), had a sensitivity of 87.34% and a specificity of 93.60%. Conclusion The low expression of serum ZAG and high expression of 3-NT and HDAC6 in patients with VCI are closely related to MoCA score, and the combination of the three has high diagnostic value for VCI. |
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