| Objective To analyze the efficacy of joint of vaginal ultrasound and serum fatty acid binding protein 4(FABP4) and platelet reactive protein-1(TSP-1) in the diagnosis of threatened miscarriage in early pregnancy. Methods From November 2023 to November 2024, 145 patients with threatened miscarriage in early pregnancy admitted to Wuhan Traditional Chinese Medicine Hospital were served as the monitored group, and 145 pregnant women with normal pregnancy tests were served as the control group. Vaginal ultrasound examination was performed on all pregnant women, and the resistance index(RI) and peak systolic velocity(PSV) of the arterial blood flow in interstitial space of the gestational sac were recorded. Enzyme linked immunosorbent assay was carried out to measure serum FABP4 and TSP-1. Pearson method was used to discuss the correlation between vaginal ultrasound parameters, serum FABP4, TSP-1 with estradiol, progesterone, and β-human chorionic gonadotropin(β-HCG) in pregnant women with threatened miscarriage in early pregnancy. Multivariate logistic regression was performed to discuss the influencing factors of threatened miscarriage in early pregnancy. Receiver operating characteristic(ROC) curve was plotted to analyze the diagnostic efficacy of joint of vaginal ultrasound, serum FABP4 and TSP-1 for threatened miscarriage in early pregnancy. Results For the control group, the monitored group had conspicuously lower serum estradiol, progesterone, β-HCG, and PSV, and conspicuously higher RI, serum FABP4, and TSP-1(P<0.05). RI, serum FABP4, TSP-1 in pregnant women with threatened miscarriage during early pregnancy were negatively correlated with estradiol, progesterone, and β-HCG, while PSV was positively correlated with estradiol, progesterone, and β-HCG(P<0.05). Multivariate logistic regression found that vaginal ultrasound parameters RI, serum FABP4 and TSP-1 were risk factors for threatened miscarriage in early pregnancy, while parameters PSV was protective factors(P<0.05). ROC curve showed that the area under the curve(AUC) of RI, PSV, serum FABP4, TSP-1, and their joint in diagnosing threatened miscarriage in early pregnancy was 0.849, 0.823, 0.839, 0.814, and 0.978, respectively. The AUC of joint diagnosis was clearly better than that of RI, PSV, FABP4, and TSP-1 diagnosis alone(Z=4.942, 5.221, 4.985, 5.404, P<0.05). Conclusion Serum FABP4 and TSP-1 in pregnant women with threatened miscarriage in early pregnancy are elevated, and the joint of the two with vaginal ultrasound can conspicuously improve the diagnostic efficacy for threatened miscarriage in early pregnancy. |
