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| 血清circIPO7 circNRIP1对局部晚期鼻咽癌患者诱导化疗近期疗效的预测价值 |
| The predictive value of serum circIPO7 and circNRIP1 in short-term efficacy of induction chemotherapy for locally advanced nasopharyngeal carcinoma |
| 投稿时间：2025-05-26 |
| DOI：10.3969/j.issn.1000-0399.2026.03.011 |
| 中文关键词: 鼻咽癌 局部晚期 诱导化疗 环状RNA核转运蛋白7 核受体相互作用蛋白1 |
| 英文关键词: Nasopharyngeal carcinoma Locally advanced stage Induction chemotherapy CircIPO7 CircNRIP1 |
| 基金项目: |
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| 中文摘要: |
| 目的 探究血清环状RNA核转运蛋白7(circIPO7)、核受体相互作用蛋白1(circNRIP1)对局部晚期鼻咽癌患者诱导化疗近期疗效的预测价值。方法 回顾性分析2022年1月至2024年3月在达州市中心医院耳鼻咽喉头颈外科进行诱导化疗联合同步放化疗的98例局部晚期鼻咽癌患者资料。根据诱导化疗后近期疗效将患者分为化疗敏感组（n=60）和化疗耐药组（n=38）。比较两组患者血清circIPO7、circNRIP1表达水平及临床病理特征的差异，采用logistic回归分析局部晚期鼻咽癌患者诱导化疗近期疗效的影响因素，绘制受试者工作特征（ROC）曲线分析诱导化疗前局部晚期鼻咽癌患者血清circIPO7、circNRIP1表达水平对诱导化疗近期疗效的预测价值。结果 临床分期Ⅳa期、颈动脉鞘区受侵、咽旁间隙受侵的局部晚期鼻咽癌患者的血清circIPO7、circNRIP1表达水平高于Ⅲ期、颈动脉鞘区未受侵、咽旁间隙未受侵的局部晚期鼻咽癌患者，差异有统计学意义（P<0.05）；化疗耐药组的血清circIPO7、circNRIP1表达水平高于化疗敏感组，差异有统计学意义（P<0.05）;logistic回归分析显示，血清circIPO7、circNRIP1表达水平增加是局部晚期鼻咽癌诱导化疗耐药的危险因素（P<0.05）；血清circIPO7、circNRIP1表达水平预测诱导化疗近期疗效的曲线下面积（AUC）为0.859(95%CI:0.778～0.940)和0.803(95%CI:0.707～0.899)，联合预测的AUC为0.943(95%CI:0.899～0.987)，联合预测的AUC高于单独预测（Z=4.326、P=0.024;Z=5.591、P=0.007）。结论 诱导化疗前血清circIPO7、circNRIP1表达水平是预测局部晚期鼻咽癌患者诱导化疗近期疗效的潜在标志物。 |
| 英文摘要: |
| Objective To study the predictive value of serum circular RNA importin 7(circIPO7) and nuclear receptor-interacting protein 1(circNRIP1) in the short-term efficacy of induction chemotherapy for locally advanced nasopharyngeal carcinoma. Methods Patients with locally advanced nasopharyngeal carcinoma who underwent induction chemotherapy combined with concurrent chemoradiotherapy in Dazhou Central Hospital from January 2022 to March 2024 were selected for analysis. The serum was collected before induction chemotherapy and the expression levels of circIPO7 and circNRIP1 were detected. The short-term efficacy of induction chemotherapy was evaluated, and patients were divided into the chemotherapy sensitive group(n=60) and chemotherapy resistant group(n=38). The expression levels of circIPO7 and circNRIP1 in serum and clinicopathological features of the two groups were evaluated. Logistic regression model was used to analyze the influencing factors of the short-term efficacy of induction chemotherapy, and the receiver operating characteristic curve of circIPO7 and circNRIP1 expression levels before induction chemotherapy in predicting the short-term efficacy of induction chemotherapy was drawn and the predictive value was analyzed. Results The expression levels of circIPO7 and circNRIP1 in serum of locally advanced nasopharyngeal carcinoma patients with stage Ⅳa, carotid sheath area invasion and parapharyngeal space invasion were higher than those with stage Ⅲ and without carotid sheath area invasion and parapharyngeal space invasion, and the difference was statistically significant(P<0.05). The expression levels of circIPO7 and circNRIP1 in serum of chemotherapy resistant group were higher than those of chemotherapy sensitive group, and the difference was statistically significant(P<0.05). Logistic regression analysis showed that increased expression levels of circIPO7 and circNRIP1 in serum were risk factors for chemotherapy resistance of locally advanced nasopharyngeal carcinoma(P<0.05). The area under the curve(AUC) of serum circIPO7 and circNRIP1 expression levels before induction chemotherapy in predicting the short-term efficacy of induction chemotherapy was 0.859(95%CI:0.778～0.940) and 0.803(95%CI:0.707～0.899), and the AUC of combined prediction was 0.943(95%CI:0.899～0.987), the AUC of combined prediction was higher than that of individual prediction(Z=4.326, P=0.024, Z=5.591, P=0.007). Conclusion Serum circIPO7 and circNRIP1 are potential markers for predicting the short-term efficacy of induction chemotherapy for locally advanced nasopharyngeal carcinoma. |
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