| Objective To investigate the correlation between chemokine ligand 3 (CCL3) and chemokine ligand 5 (CCL5) with rheumatoid arthritis (RA) complicated by osteoporosis (OP). Methods A total of 200 RA patients treated at the Third Affiliated Hospital of Anhui Medical University (Hefei First People’s Hospital) from January 2022 to December 2025 were selected as the study subjects. They were divided into an OP group (114 cases) and a non-OP group (86 cases) based on whether their bone mineral density (BMD) was ≤ -2.5. Enzymelinked immunosorbent assay (ELISA) was employed to measure serum levels of CCL3 and CCL5. Univariate logistic regression was employed to preliminarily screen for relevant indicators. Variables found to be significant in the univariate analysis were included in the multivariate logistic regression for further screening. Receiver operating characteristic (ROC) curve was used to analyse the diagnostic value. Results In the comparison of general data, the levels of CCL3 and CCL5 in the OP group were higher than those in the non-OP group (P<0.05). Univariate logistic regression analysis results showed that disease duration (OR=1.004, P = 0.005, 95% CI: 1.001 - 1.007), tender joint count (OR=1.030, P = 0.042, 95% CI: 1.001 - 1.059), swollen joint count (OR=1.034, P = 0.024, 95% CI: 1.004 - 1.065), CCL3 (OR=1.010, P<0.001, 95% CI: 1.007 - 1.014), and CCL5 (OR=1.007, P<0.001, 95% CI: 1.004 - 1.009) were all risk factors for RA complicated with OP. Multivariate logistic regression analysis, incorporating variables significant in the univariate analysis, revealed that CCL3 (OR=1.010, P<0.001, 95% CI: 1.007 ~ 1.014) and CCL5 (OR=1.007, P<0.001, 95% CI: 1.004 ~ 1.009) were independent risk factors for RA complicated with OP. The area under the curve (AUC) for diagnosing RA with OP using CCL3 was 0.857, with a specificity of 86.3% and a sensitivity of 73.0%. The AUC for CCL5 was 0.792 (specificity 66.0%, sensitivity 79.8%). When these two indicators were combined, the AUC for diagnosing RA with OP was 0.905 (specificity 77.2%, sensitivity 89.7%) (combined model vs. CCL3: Z=2.21, P=0.027; combined model vs. CCL5: Z=3.21, P=0.001). Conclusion CCL3 and CCL5 are significantly correlated with RA complicated with OP and have certain predictive value for this condition. |
