文章摘要
急性腹部闭合性损伤患者预后不良的影响因素及预测模型构建
Prognostic factors and prediction model construction for poor outcomes in patients with acute blunt abdominal trauma
投稿时间:2025-06-26  
DOI:10.3969/j.issn.1000-0399.2026.04.012
中文关键词: 闭合性腹部创伤  预后  列线图预测模型
英文关键词: Blunt abdominal trauma  Prognosis  Nomogram prediction model
基金项目:
作者单位E-mail
张熙 448000 湖北荆门 荆门市人民医院结直肠肛门外科  
丁晓龙 448000 湖北荆门 荆门市人民医院急诊科 EICU 459128904@qq.com 
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中文摘要:
      目的 探讨急性腹部闭合性损伤患者预后不良的关键影响因素,构建并验证列线图预测模型。方法 回顾性纳入荆门市人民医院收治的2020年8月至2024年8月297例急性腹部闭合性损伤患者,根据院内死亡情况分为死亡组(n=33)与存活组(n=264)。采用Lasso回归筛选变量,多因素logistic回归确定独立危险因素,据此构建列线图模型。通过Bootstrap法(1 000次重抽样)进行内部验证,并利用校准曲线、受试者工作特征(ROC)曲线和决策曲线分析(DCA)评估模型性能。结果 单因素分析显示,死亡组在年龄、糖尿病史、受伤至就医时间、创伤严重程度(ISS)评分、肝脾损伤分级、失血性休克比例及血乳酸水平等方面均高于存活组(P<0.05)。多因素logistic回归分析结果显示,ISS评分≥16分、肝AAST-OIS分级≥Ⅳ级、失血性休克、血乳酸≥4 mmol/L、受伤至就医时间≥2 h为预后不良的独立危险因素(P<0.05)。基于此构建的预测模型区分度良好(AUC=0.874),校准度佳(C-index=0.874),且决策曲线显示具有临床实用性。结论 基于危险因素ISS评分、肝AAST-OIS分级、失血性休克、血乳酸偏高、受伤至就医时间构建的列线图模型能有效预测不良预后风险,可为临床分层管理提供量化工具。
英文摘要:
      Objective To explore the key influencing factors for poor prognosis in patients with acute blunt abdominal trauma and to construct and validate a nomogram prediction model. Methods A total of 297patients with acute blunt abdominal trauma admitted to Jingmen People's Hospital from August 2020 to August 2024 were retrospectively included and divided into a death group (n=33) and a survival group (n =264) based on in-hospital mortality. Variables were screened using Lasso regression, and independent risk factors were identified by multivariate logistic regression to construct a nomogram model. Internal validation was performed via the bootstrap method (1 000 resamples). Model performance was evaluated using calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA). Results Univariate analysis showed that the death group had significantly higher values than the survival group in terms of age, diabetes history, time from injury to medical consultation, Injury Severity Score (ISS), grade of liver/spleen injury (AAST-OIS), proportion of hemorrhagic shock, and blood lactate level (all P<0.05). Multivariate logistic regression analysis identified ISS score ≥16, liver AAST-OIS grade ≥IV, hemorrhagic shock, blood lactate ≥4 mmol/L, and time from injury to medical care ≥2 h as independent risk factors for poor prognosis (all P<0.05). The prediction model constructed based on these factors demonstrated good discrimination (AUC=0.874), excellent calibration (C-index=0.874), and clinical utility as indicated by DCA. Conclusion The nomogram model based on risk factors including ISS score, liver AAST-OIS grade, hemorrhagic shock, elevated blood lactate, and prolonged time from injury to medical care can effectively predict the risk of poor prognosis, providing a quantitative tool for clinical stratified management.
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