| Objective To explore the correlation between the expression of high-sensitivity C-reactive protein to albuminratio ratio(HCAR), eosinophils, D-dimer and the severity of AECOPD, as well as the risk factors affecting prognosis. Methods A total of 249 AECOPD inpatients with complete clinical data in the Hospital from January 2023 to December 2023 were selected as study subjects. Based on the presence or absence of respiratory failure, the patients were divided into the respiratory failure group(72 cases) and non-respiratory failure group(177 cases). Using telephone and outpatient follow-up methods, with a continuous follow-up of one year, patients with acute exacerbations that require hospitalization at least once or even death within one year were classified as the poor prognosis group(108 cases), while those who did not require hospitalization were classified as the good prognosis group(141 cases). The general clinical data and laboratory test indicators of patients in each group to were analyzed to identify risk factors for poor prognosis in AECOPD patients. Results Patients in the respiratory failure group had higher rates of concomitant pulmonary heart disease, longer hospital stays, higher NEU, hs-CRP, HCAR, and D-D levels than those in the non-respiratory failure group. Conversely, they had lower BMI, EOS, and ALB levels(P<0.05). The incidence of pulmonary heart disease and respiratory failure, as well as HCAR and D-D, were higher in the poor prognosis group than in the good prognosis group,the EOS level was lower than that of the group with good prognosis(P<0.05). Logistic regression analysis showed that elevated HCAR, D-D, concomitant pulmonary heart disease, and respiratory failure were risk factors for poor prognosis in AECOPD(P<0.05). Conclusion AECOPD patients with respiratory failure and poor prognosis have high expression of HCAR and D-D, and reduced EOS. The combined detection of HCAR, EOS, and D-D has high clinical application value in evaluating the severity and prognosis of AECOPD. |
