| Objective To investigate the factors influencing the outcomes of catheter drainage combined with antimicrobial therapy for patients with primary liver abscess of unknown origin(PLAC). Methods A retrospective analysis was conducted on the medical records of 160 patients admitted to the First People's Hospital of Wuhu from March 2021 to March 2025 for treatment of PLAC, who underwent local abscess catheterization and drainage combined with antimicrobial therapy. Based on treatment outcomes within 30 days of admission, the patients were divided into an observation group(45 cases, not cured) and a control group(115 cases, cured). Univariate and multivariate logistic regression models were used to identify influencing factors, and receiver operating characteristic(ROC) curves were plotted to evaluate predictive performance. Results Chills and fever were the most common symptoms in both groups. The proportion of patients in the observation group exhibiting severe sepsis-related symptoms, such as dyspnea, cough, and delirium, was higher than that in the control group(P<0.05). Multivariate logistic regression analysis revealed that local abscess characteristics(abscess compartmentalization, pus characteristics, and abscess diameter) and comprehensive clinical characteristics(age) were all independent predictors of treatment efficacy(P<0.05). Receiver operating characteristic(ROC) curve results showed that the area under the curve(AUC) for predicting the 30-day efficacy of PLAC catheter drainage combined with antimicrobial therapy was 0.818, 0.728, 0.595, and 0.844 for age, abscess compartmentalization, pus characteristics, and abscess diameter, respectively. The combined AUC for these four factors was 0.979, with sensitivity and specificity of 0.889 and 0.957, respectively. Conclusion Age, abscess compartmentalization, viscous pus, abscess diameter, and pus are identified as factors influencing the 30-day efficacy of PLAC catheter drainage combined with antimicrobial therapy. All of these factors demonstrated some predictive value for the 30-day efficacy of this treatment regimen, with the combined data showing superior predictive performance. |
