| Objective To investigate the expression level of exosomal microRNA-19b-3p(miR-19b-3p) in the plasma of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and its clinical significance. Methods A total of 104 patients with AECOPD treated in the Second Central Hospital of Baoding City from January 2022 to June 2023 were selected as the observation group, and another 104 patients with stable COPD treated during the same period were selected as the control group. The plasma exosomes of the two groups of patients were collected. The difference in exosomal miR-19b-3p expression level between two groups of patients was detected. According to the prognosis of the patients, the patients in the observation group were further divided into the good prognosis group(n=43) and the poor prognosis group(n=61), and the relationship between the level of miR-19b-3p in plasma exosomes and the prognosis of patients with AECOPD was analyzed. Logistic regression was used analyze the risk factors for poor prognosis in patients with AECOPD. Results The plasma exosomal miR-19b-3p level in the observation group was higher than that in the control group(P<0.05). During the follow-up period, 61 out of 104 patients in the observation group had poor prognosis with a poor prognosis rate of 58.65%; while 28 out of 104 patients in the control group had poor prognosis with a poor prognosis rate of 26.92%. The proportion of patients with a history of smoking, drinking, high plasma exosomal miR-19-3p level, and number of comorbidities ≥3 in the poor prognosis group was significantly higher than that in the good prognosis group(all P<0.05), and the average disease duration was longer than that in the good prognosis group(P<0.05). Logistic regression analysis showed that history of smoking, drinking, disease duration, plasma exosomal miR-19b-3p, disease duration, and number of comorbidities3 were all risk factors for poor prognosis in AECOPD patients(P<0.05). Conclusion The expression level of plasma exosomal miR-19b-3p is higher in AECOPD patients than in COPD stable patients and is associated with poor prognosis in AECOPD patients, which may become one of the prognostic predictors in AECOPD patients. |
