| Objective To explore the diagnostic value of combined detection of serum dehydroepiandrosterone sulfate（DHEA-S）, thioredoxin-interacting protein（TXNIP）, and anti-Müllerian hormone（AMH） for polycystic ovary syndrome（PCOS）. Methods Totally 91 patients with PCOS who visited the 910 th Hospital of the Joint Service Support Force of PLA from January 2023 to January 2025 were selected as the PCOS group, and 91 healthy women who experienced physical check ups were selected as the control group. Enzyme-linked immunosorbent assay（ELISA） was employed to detect the levels of serum DHEA-S, TXNIP and AMH. Logistic analysis was used to investigate the factors influencing PCOS. In addition, receiver operating characteristic（ROC） curve was employed to explore the diagnostic value of serum DHEA-S, TXNIP and AMH for PCOS. Results The levels of serum DHEA-S, TXNIP and AMH in the PCOS group were higher than those in the control group（P<0.05）. Serum DHEA-S, TXNIP and AMH were the influencing factors for PCOS（P<0.05）. The area under the curve for the combined diagnosis of PCOS using serum DHEA-S, TXNIP, and AMH was superior to that of the individual diagnoses of serum DHEA-S, TXNIP, and AMH(Zcombination-DHEA-S =5.069, P<0.001; Zcombination-TXNIP = 4.236, P<0.001; Zcombination-AMH =4.521, P<0.001). Conclusion The levels of serum DHEA-S, TXNIP and AMH are highly expressed in patients with PCOS. In addition, the combined detection of the three can enhance the diagnostic value for PCOS. |
