| Objective To explore the relationship between serum irisin, Nesfatin-1 and atherosclerosis(AS) in patients with subclinical hypothyroidism(SCH) complicated with obesity. Methods A retrospective analysis was conducted on the clinical data of 144 patients with SCH enrolled in the Department of Endocrinology, Fenyang Hospital of Shanxi Province, from January 2024 to January 2025. According to the presence or absence of obesity, the patients were divided into the obese group(n=86) and non-obese group(n=58). Meanwhile, 45 healthy subjects undergoing physical examination were enrolled as the control group. The serum levels of irisin and Nesfatin-1 were compared among the three groups. SCH patients were re-grouped according to whether AS occurred, and the clinical data were compared between the AS group and non-AS group. Logistic regression analysis was used to analyze the influencing factors of AS in SCH patients complicated with obesity. Receiver operating characteristic(ROC) curve analysis was further performed to evaluate the predictive value of irisin and Nesfatin-1 for AS risk in this population. Results Compared with the control group, the obese group and non-obese group presented significantly increased serum irisin and decreased Nesfatin-1 levels(P<0.05). Univariate analysis showed that, compared with the non-obese group, the obese group had higher irisin [(861.35±108.47) ng/mL vs. (759.62±99.85) ng/mL], lower Nesfatin-1[(3.64±0.63) ng/mL vs. (4.50±0.71) ng/mL], as well as higher body mass, TSH and LDL-C, with statistically significant differences(P<0.05). Multivariate analysis indicated that elevated TSH, LDL-C and irisin, together with reduced Nesfatin-1, were independent risk factors for AS in SCH patients complicated with obesity(P<0.05). ROC analysis revealed that the AUC value of irisin and Nesfatin-1 in predicting AS risk was 0.767 and 0.841, respectively, and the combined predictive AUC reached 0.893, which was significantly higher than that of single index prediction(P<0.05). Conclusion The serum irisin level in patients with SCH complicated with obesity is significantly increased, and the serum NesfatiN-1 level is significantly decreased. Moreover, the levels of irisin and NesfatiN-1 are independently associated with the occurrence of AS, which can predict the occurrence of AS in patients with SCH complicated with obesity. |
