| Objective To construct an evidence-based traditional Chinese medicine(TCM) characteristic nursing protocol for cancerrelated fatigue(CRF) in patients with malignant solid tumors and to explore its efficacy. Methods Using the convenience sampling method, 110 patients with CRF due to malignant solid tumors who were admitted to Foshan Hospital of Traditional Chinese Medicine from November 2024 to July 2025 and underwent long-term follow-up were selected. They were randomly divided into an experimental group and a control group using a computer-generated blind selection method, with 55 cases in each group. The control group received conventional nursing care for CRF, while the experimental group, based on evidence-based practice, combined with clinical experience, group discussions, and the Delphi expert consultation method, developed a TCM characteristic nursing protocol for CRF in patients with malignant solid tumors. Both groups were subjected to a 5-week intervention. Changes in cancer fatigue scale(CFS), TCM syndrome scores, systemic immune-inflammation index(SII), serum pro-inflammatory cytokine levels and Karnofsky Performance Status(KPS) were observed before and after the intervention in both groups. Results Before the intervention, there were no statistically significant differences in baseline data between the two groups(P>0.05). After the intervention, the CFS scores, TCM syndrome scores, SII and serum pro-inflammatory cytokine levels in both groups were significantly reduced, and the degree of improvement in the experimental group was significantly better than that in the control group, with all differences being statistically significant(P<0.05). The KPS scores of patients in both groups were significantly increased, and the scores in the experimental group were significantly higher than those in the control group, with the difference being statistically significant(P< 0.05). Conclusion The implementation of an evidence-based characteristic nursing protocol of traditional Chinese medicine for patients with malignant solid tumors and CRF exhibits scientific validity and practicality. It can effectively enhance the alleviation of CRF, decrease the scores of TCM syndromes, strengthen the body,s immune and inflammatory states, mitigate inflammatory responses, and elevate the quality of life. |
